Neutrophil Gelatinase-Associated Lipocalin and Interleukin-18 in the Prediction of Acute Kidney Injury in Sepsis Patients.

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of General Medicine Pub Date : 2024-12-18 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S489826
Yajing Liu, Chunming Li, Xiaoya Yang, Shufen Guo, Zhaobo Cui, Hongshan Kang, Zhen Ma, Huiqing Wang
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引用次数: 0

Abstract

Objective: We assessed the predictive value of blood neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) in predicting the onset of acute kidney injury (AKI) in sepsis patients in the intensive care unit (ICU).

Methods: In this retrospective analysis, we examined the medical records of sepsis patients admitted to the ICU. After ICU admission, blood samples were taken at 0 h, 6 h, 12 h, 24 h, and 48 h. Using an enzyme-linked immunosorbent assay, the concentrations of serum creatinine, NGAL, and IL-18 were determined.

Results: This study comprised a total of 197 participants, 104 of whom had AKI and 93 of whom did not. Blood concentrations of NGAL and IL-18 increased prior to serum creatinine levels. Between 6-48 hours after ICU administration, NGAL and IL-18 levels in the AKI group were considerably higher than those in the non-AKI group, and creatinine levels between the two groups were significantly different after 48 hours. Based on receiver operating characteristic (ROC) curve analysis, the area under the curve of NGAL and IL-18 for predicting AKI was 0.781 and 0.883, respectively.

Conclusion: Blood NGAL and IL-18 are potential biomarkers for the early prediction of AKI in sepsis patients in the ICU.

中性粒细胞明胶酶相关脂钙素和白细胞介素-18在脓毒症患者急性肾损伤预测中的作用。
目的:评价血中性粒细胞明胶酶相关脂钙素(NGAL)和白细胞介素-18 (IL-18)对重症监护病房(ICU)脓毒症患者急性肾损伤(AKI)发生的预测价值。方法:回顾性分析ICU收治的脓毒症患者的医疗记录。入院后0 h、6 h、12 h、24 h、48 h采血,采用酶联免疫吸附法测定血清肌酐、NGAL、IL-18浓度。结果:本研究共纳入197名参与者,其中104人患有AKI, 93人没有AKI。NGAL和IL-18的血药浓度高于血清肌酐水平。给药后6 ~ 48 h, AKI组NGAL、IL-18水平明显高于非AKI组,48 h后两组肌酐水平差异有统计学意义。根据受试者工作特征(ROC)曲线分析,NGAL和IL-18预测AKI的曲线下面积分别为0.781和0.883。结论:血NGAL和IL-18是早期预测ICU脓毒症患者AKI的潜在生物标志物。
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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