Chrydintins A and B, two new sesquiterpenoids from Chrysanthemum indicum with cardioprotective activities.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-23 DOI:10.1080/14786419.2024.2444570

Guanghui Zhang, Chunxiang Zhou, Donglin Wang, Junxia Liu, Xinyong Zhao

引用次数: 0

Abstract

Chrydintins A (1) and B (2), two new sesquiterpenoids were isolated from Chrysanthemum indicum., together with four known ones identified as 9-hydroxyeudesma-4,7(11)-dien-6-one (3), (7S,9S,10S)-9-hydroxy-11-methoxyeudesm-4-en-6-one (4), curcumenone (5), and polydactin B (6), respectively. The structures of isolated compounds were determined by HR-ESI-MS, NMR analysis, and quantum chemical calculation. The in vitro cardioprotective activities of all compounds were studied on H₂O₂-injured H9C2 cells using MTT assay method. Compound 5 exhibited considerable protective effect with cell viability at 81.45 ± 1.07%.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.