Changes of peripheral serotonin in the psychosocially stressed rats treated with linden honey.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-23 DOI:10.1080/14786419.2024.2443487

Ljubica Gavrilović, Vesna Stojiljković, Vojislav Stanić, Nebojša Jasnić, Snežana Pejić, Marija Pantelić, Snežana B Pajović, Slađana Tanasković

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Abstract

This study aimed to investigate the effects of linden honey in maintaining the stability of peripheral serotonergic system in the psychosocially stressed rats. In this experiment we examined concentration of serotonin (5-HT) in Serbian linden honey, as well as concentrations of 5-HT and MAO A activity in the blood of chronically stressed rats treated with linden honey. The investigated parameters were quantified using HPLC method with electrochemical detector, HPLC method with a fluorescent detector, and assay of enzyme activities. An important result of this study is that using analytical chemistry methods we have detected 5-HT in linden honey from Serbia for the first time. Also, we found that treatment with linden honey in the socially isolated animals increased concentration of 5-HT and decreased MAO A activity. Our results may by important in the research of the role of linden honey in maintaining stability of peripheral serotonergic system in stress condition.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.