Delivery vehicles for light-mediated drug delivery: microspheres, microbots, and nanoparticles: a review.

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Targeting Pub Date : 2025-01-03 DOI:10.1080/1061186X.2024.2446636

Engi Nadia Massoud, Mariana Katharine Hebert, AishwaryaRaksha Siddharthan, Tyler Ferreira, Abid Neron, Mary Goodrow, Tracie Ferreira

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引用次数: 0

Abstract

This review delves into the evolving landscape of mediated drug delivery, focusing on the versatility of a variety of drug delivery vehicles such as microspheres, microbots, and nanoparticles (NPs). The review also expounds on the critical components and mechanisms for light-mediated drug delivery, including photosensitizers and light sources such as visible light detectable by the human eye, ultraviolet (UV) light, shorter wavelengths than visible light, and near-infra-red (NIR) light, which has longer wavelength than visible light. This longer wavelength has been implemented in drug delivery for its ability to penetrate deeper tissues and highlighted for its role in precise and controlled drug release. Furthermore, this review discusses the significance of these drug delivery vehicles towards a spectrum of diverse applications spanning gene therapy, cancer treatment, diagnostics, and microsurgery, and the materials used in the fabrication of these vehicles encompassing polymers, ceramics, and lipids. Moreover, the review analyses the challenges and limitations of such drug delivery vehicles as areas of improvement to provide researchers with valuable insights for addressing current obstacles in the progression of drug delivery. Overall, this review underscores the potential of light-mediated drug delivery to revolutionise healthcare and personalised medicine, providing precise, targeted, and effective therapeutic interventions.

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光介导的药物递送载体：微球、微机器人和纳米颗粒：综述。

这篇综述深入研究了介导药物传递的发展前景，重点是各种药物传递载体的多功能性，如微球、微机器人和纳米颗粒（NPs）。综述了光介导药物传递的关键成分和机制，包括光敏剂和光源，如人眼可检测到的可见光、波长比可见光短的紫外线和波长比可见光长的近红外光。这种较长的波长已被用于药物输送，因为它能够穿透更深的组织，并在精确和受控的药物释放中发挥重要作用。此外，本文还讨论了这些药物传递载体在基因治疗、癌症治疗、诊断和显微外科等多种应用中的意义，以及用于制造这些载体的材料，包括聚合物、陶瓷和脂质。此外，本文还分析了这些药物递送载体的挑战和局限性，作为改进的领域，为研究人员解决当前药物递送进展中的障碍提供了有价值的见解。总的来说，这篇综述强调了光介导药物传递的潜力，以彻底改变医疗保健和个性化医疗，提供精确、有针对性和有效的治疗干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.