Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models.

IF 4.6 2区 医学 Q2 IMMUNOLOGY
Inflammopharmacology Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI:10.1007/s10787-024-01612-x
Muhammad Muzammil Nazir, Iqra Farzeen, Shahla Fasial, Asma Ashraf
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引用次数: 0

Abstract

Berberine (BBR), an alkaloid derivative mostly found in Oregon grapes and barberry shoots, has several medical properties, including anti-microbial, anti-tumorigenic, and anti-inflammatory properties. As such, it is a superior alternative to presently recommended medications. From previous researches, which showed that BBR has anti-arthritic qualities by blocking a number of inflammatory signalling pathways. Furthermore, it has been demonstrated that BBR attenuates Beclin-1, which reduces autophagy-mediated survival of mature adipocytes. BBR has also been identified as an AhR inducer and a promoter of Treg differentiation. Berberine has been shown in earlier studies to be useful in treating rheumatoid arthritis (RA) in animal models. The pharmacological effects and possible action pathway of Berberine were evaluated in this study. We looked through three databases-PubMed, Web of Science, and Google Scholar-for pertinent research published from the time the databases were created and August 2024. This risk-of-bias measure was used to evaluate the methodological quality. Utilising RevMan 5.4, the statistical analysis was conducted. There were 12 studies in this research with 175 animals. The findings showed that Berberine lowers the levels of IL-1β, IL-17, IL-6, IL-10, and TNF-α), paw swelling, and histopathological scores. These connected to the anti-inflammatory, anti-oxidative stress, and osteoprotective qualities of berberine. Nonetheless, further superior animal research is required to evaluate berberine impact on rheumatoid arthritis (RA). Additionally, more research is needed to validate berberine safety. Considering the significance of the active component, further research is needed to determine the best dose and increase berberine bioavailability.

黄连素在类风湿关节炎中的作用:动物模型中其抗炎和免疫调节机制的综合综述和荟萃分析。
小檗碱(BBR)是一种生物碱衍生物,主要存在于俄勒冈葡萄和小檗芽中,具有多种医学特性,包括抗微生物、抗肿瘤和抗炎特性。因此,它是目前推荐的药物的一个更好的选择。从之前的研究来看,BBR通过阻断一些炎症信号通路具有抗关节炎的特性。此外,研究表明,BBR可减弱Beclin-1,从而降低成熟脂肪细胞自噬介导的存活。BBR也被确定为AhR诱导剂和Treg分化的启动子。在早期的研究中,小檗碱在治疗类风湿性关节炎(RA)的动物模型中是有用的。本研究对小檗碱的药理作用及可能的作用途径进行了评价。我们查看了三个数据库——pubmed、Web of Science和谷歌scholar——从数据库创建到2024年8月之间发表的相关研究。这种偏倚风险测量被用来评估方法学的质量。利用RevMan 5.4进行统计分析。这项研究共进行了12项研究,涉及175只动物。结果显示,小檗碱可降低小鼠IL-1β、IL-17、IL-6、IL-10和TNF-α水平,降低足跖肿胀和组织病理学评分。这些都与小檗碱的抗炎、抗氧化应激和骨保护特性有关。尽管如此,需要进一步的动物研究来评估小檗碱对类风湿关节炎(RA)的影响。此外,还需要更多的研究来验证小檗碱的安全性。考虑到活性成分的重要性,需要进一步研究确定最佳剂量,提高小檗碱的生物利用度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Inflammopharmacology
Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY
CiteScore
8.00
自引率
3.40%
发文量
200
期刊介绍: Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]
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