Percutaneous coronary intervention (PCI) in patients of rheumatoid arthritis(RA): A systematic review and meta-analysis

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Indian heart journal Pub Date : 2025-01-01 DOI:10.1016/j.ihj.2024.12.002

Shobhit Piplani , Anastas Kostojchin , Steve Kong , Aakanksha Sharma , Donclair Brown , Vladimir Jelic , Salil Chaturvedi , Vishal Reddy , Katherine Chang Pieri , Ezekiel Akpan , Tamara Simpson , Wenzhen Xiao , Minas Sakellakis , Aayushi Sharma , Priyanshu Jain , Miroslav Radulovic

{"title":"Percutaneous coronary intervention (PCI) in patients of rheumatoid arthritis(RA): A systematic review and meta-analysis","authors":"Shobhit Piplani , Anastas Kostojchin , Steve Kong , Aakanksha Sharma , Donclair Brown , Vladimir Jelic , Salil Chaturvedi , Vishal Reddy , Katherine Chang Pieri , Ezekiel Akpan , Tamara Simpson , Wenzhen Xiao , Minas Sakellakis , Aayushi Sharma , Priyanshu Jain , Miroslav Radulovic","doi":"10.1016/j.ihj.2024.12.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>The present study aims to investigate the outcomes of Percutaneous coronary intervention (PCI) in patients with Rheumatoid arthritis (RA).</div></div><div><h3>Methods</h3><div>A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to 15th September 2023. All statistical analyses were conducted using Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result was reported in the odds ratio (OR) and the corresponding 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>Eight observational studies were selected to conduct the analysis. A statistically significant increase in major adverse cardiovascular event (MACE) was seen in RA patients after undergoing PCI as compared to the control group (OR = 1.18 (1.16, 1.21); <em>p</em> < 0.00001; I2 = 0 %). There was no significant difference found in the long-term revascularization outcome between the RA and non-RA patients (OR = 1.18 (0.81, 1.71); <em>p</em> = 0.39; I2 = 93 %). Survival rates of all-cause mortality in the long-term outcome were statistically insignificant among the two groups (OR = 1.21 (0.84, 1.74); <em>p</em> = 0.31; I2 = 99 %).</div></div><div><h3>Conclusion</h3><div>Percutaneous coronary intervention is an important intervention to reduce morbidity and mortality but special precautions and attention should be made when it comes to patients with RA. Different precautions such as close monitoring for medication interaction, and tailored post-procedural care are essential in reducing morbidity and mortality.</div></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"77 1","pages":"Pages 7-13"},"PeriodicalIF":1.4000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian heart journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0019483224005662","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

The present study aims to investigate the outcomes of Percutaneous coronary intervention (PCI) in patients with Rheumatoid arthritis (RA).

Methods

A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to 15th September 2023. All statistical analyses were conducted using Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result was reported in the odds ratio (OR) and the corresponding 95 % confidence interval (CI).

Results

Eight observational studies were selected to conduct the analysis. A statistically significant increase in major adverse cardiovascular event (MACE) was seen in RA patients after undergoing PCI as compared to the control group (OR = 1.18 (1.16, 1.21); p < 0.00001; I2 = 0 %). There was no significant difference found in the long-term revascularization outcome between the RA and non-RA patients (OR = 1.18 (0.81, 1.71); p = 0.39; I2 = 93 %). Survival rates of all-cause mortality in the long-term outcome were statistically insignificant among the two groups (OR = 1.21 (0.84, 1.74); p = 0.31; I2 = 99 %).

Conclusion

Percutaneous coronary intervention is an important intervention to reduce morbidity and mortality but special precautions and attention should be made when it comes to patients with RA. Different precautions such as close monitoring for medication interaction, and tailored post-procedural care are essential in reducing morbidity and mortality.

查看原文本刊更多论文

类风湿性关节炎（RA）患者的经皮冠状动脉介入治疗（PCI）：一项系统综述和荟萃分析。

目的：本研究旨在探讨经皮冠状动脉介入治疗（PCI）在类风湿关节炎（RA）患者中的效果。方法：系统检索自成立至2023年9月15日的电子数据库（PubMed/Medline、Cochrane Library和谷歌Scholar）。所有统计分析均使用Review Manager 5.4.1进行。选择符合纳入标准的研究。当发现异质性时，采用随机效应模型合并研究，并以比值比（OR）和相应的95%置信区间（CI）报告结果。结果：选取8项观察性研究进行分析。与对照组相比，接受PCI治疗的RA患者的主要不良心血管事件（MACE）有统计学意义的增加(OR = 1.18 (1.16, 1.21)；P < 0.00001；I2 = 0%)。RA和非RA患者的长期血运重建结果无显著差异(OR = 1.18 (0.81, 1.71)；P = 0.39；I2 = 93%)。两组患者长期预后全因死亡率生存率差异无统计学意义(OR = 1.21 (0.84, 1.74)；P = 0.31；I2 = 99%)。结论：经皮冠状动脉介入治疗是降低发病率和死亡率的重要干预手段，但对RA患者应特别注意。不同的预防措施，如密切监测药物相互作用，以及量身定制的术后护理，对于降低发病率和死亡率至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

52 days

期刊介绍： Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.