Association analyses of the measurements of the photopic negative response evoked by two ISCEV protocols.

IF 2.4 3区 医学 Q2 OPHTHALMOLOGY
Bing Zhang, Jiajun Wang, Yalan Wang, Yilin Jiang, Yun-E Zhao
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引用次数: 0

Abstract

Purpose: To perform association analyses between the measurements of photopic negative response (PhNR) evoked by two ISCEV protocols.

Methods: A total of 172 eyes from 72 post-operative pediatric cataract patients and 24 healthy children were enrolled. The amplitude and peak time of PhNR were analyzed in three eye groups, 1. healthy controls; 2. fellow eyes of unilaterally affected patients; 3. affected eyes. PhNR responses were measured with skin-electrodes and evoked by the ISCEV standard protocols of PhNR and light-adapted 3.0, referred to as PhNR1 and PhNR2. The correlation coefficients between PhNR1 and PhNR2 measurements were calculated. The generalized estimating equation (GEE) model of PhNR1, with PhNR2 as a predictor, was evaluated after adjusting for correlation between paired eyes.

Results: Both the amplitude (P = 0.025) and the peak time (P = 0.036) of PhNR1 showed a significant difference among the three eye groups, which was not observed in PhNR2. The four correlation coefficients (Pearson, Intraclass, Lin's and Kendall's) between z-score transformed PhNR1 and PhNR2 measurements were generally moderate: 0.52, 0.52, 0.52, 0.36 for amplitude (P < 0.001), and 0.57, 0.57, 0.57, 0.36 for peak time (P < 0.001). The amplitude of PhNR1 cannot be precisely predicted by PhNR2, with a mean absolute percentage error (MAPE) of 36.7%, while the peak time of PhNR1 can be precisely predicted with a MAPE of 3.9%.

Conclusions: PhNR1 appears to be a more sensitive measure than PhNR2 for detecting eye group differences. Further research is needed to confirm this and explore its clinical applications. PhNR1 may not be entirely replaced by PhNR2 due to moderate correlation and low prediction precision in amplitude.

两种ISCEV方案引起的光负反应测量的关联分析。
目的:对两种ISCEV方案引起的光负反应(PhNR)测量结果进行关联分析。方法:选取72例术后儿童白内障患者和24例健康儿童共172只眼。分析三眼组PhNR的振幅和峰值时间。健康对照组;2. 单侧受累患者同侧眼;3. 受影响的眼睛。通过皮肤电极测量PhNR反应,并通过ISCEV标准方案PhNR和光适应3.0(称为PhNR1和PhNR2)诱发。计算PhNR1和PhNR2测量值之间的相关系数。以PhNR2为预测因子的PhNR1广义估计方程(GEE)模型在调整成对眼间的相关性后进行评估。结果:PhNR1的振幅(P = 0.025)和峰值时间(P = 0.036)在三眼组间均有显著性差异,而PhNR2组间无显著性差异。PhNR1与PhNR2测量值之间的4个相关系数(Pearson、Intraclass、Lin’s和Kendall’s)均为中等水平,振幅分别为0.52、0.52、0.52和0.36 (P)。结论:PhNR1在检测眼组差异方面比PhNR2更敏感。需要进一步的研究来证实这一点,并探索其临床应用。PhNR1可能不会被PhNR2完全取代,因为PhNR2在振幅上相关性适中,预测精度较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
398
审稿时长
3 months
期刊介绍: Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.
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