Association between moderate-to-vigorous physical activity and chronic disease risk in adults and elderly: insights from the UK Biobank study.

IF 3.2 3区 医学 Q2 PHYSIOLOGY
Frontiers in Physiology Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI:10.3389/fphys.2024.1465168
Kei Shing Ng, Jie Lian, Fan Huang, Yan Yu, Varut Vardhanabhuti
{"title":"Association between moderate-to-vigorous physical activity and chronic disease risk in adults and elderly: insights from the UK Biobank study.","authors":"Kei Shing Ng, Jie Lian, Fan Huang, Yan Yu, Varut Vardhanabhuti","doi":"10.3389/fphys.2024.1465168","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine the associations between different intensities of moderate to vigorous physical activity (MVPA) and the incidence of chronic diseases, and to assess the risk levels associated with these activities over time.</p><p><strong>Methods: </strong>A prospective cohort study (UK Biobank Activity Project) with data collected between June 2013 and December 2015 included 59,896 adults (mean age = 59.68; male = 38.03%) free from chronic diseases. Participants were categorized into tertiles based on their weekly MVPA: lowest (<224 min for males, <143 min for females), medium (224-444 min for males, 143-308 min for females), and highest (≥444 min for males, ≥308 min for females), stratified by gender. The mean onset of chronic disease symptoms occurred at 3.57 years, with participants followed up during this period. Wearable accelerometry data were used to quantify MVPA levels.</p><p><strong>Findings: </strong>Lowest tertile of MVPA were significantly correlated with increased risks of chronic disease (24%-110% increased risk) based on odds ratios (ORs), with dose-response relationship observed. In males with the lowest tertile of MVPA, significant associations were identified with type 2 diabetes mellitus (T2DM) (OR = 1.90; CI: 1.44-2.51), neurodegenerative disease (OR = 1.80; CI: 1.19-2.71), metabolic syndrome (OR = 1.34; CI: 1.18-1.53), hypertension (OR = 1.27; CI: 1.12-1.44), and atherosclerotic cardiovascular disease (ASCVD) (OR = 1.24; CI: 1.03-1.49). In females, the lowest tertile of MVPA levels were associated with increased risks of neurodegenerative disease (OR = 2.10; CI: 1.36-3.24), T2DM (OR = 1.88; CI: 1.37-2.58), cerebrovascular disease (OR = 1.61; CI: 1.12-2.29), ASCVD (OR = 1.58; CI: 1.23-2.03), metabolic syndrome (OR = 1.49; CI: 1.32-1.69), and hypertension (OR = 1.44; CI: 1.29-1.61). Longitudinally, the lowest tertile of MVPA in males showed elevated risks for neurodegenerative disease (HR = 2.13; CI: 1.24-3.66), T2DM (HR = 1.83; CI: 1.30-2.57), hypertension (HR = 1.33; CI: 1.15-1.53), metabolic syndrome (HR = 1.32; CI: 1.14-1.54), and ASCVD (HR = 1.29; CI: 1.03-1.61). In females, the lowest tertile of MVPA was associated with similar risks for ASCVD (HR = 1.59; CI: 1.16-2.20), T2DM (HR = 1.57; CI: 1.08-2.29), hypertension (HR = 1.53; CI: 1.34-1.74), and metabolic syndrome (HR = 1.50; CI: 1.29-1.73).</p><p><strong>Conclusion: </strong>Using wearable accelerometry data, this study demonstrated the quantifiable risks of chronic diseases and their development, highlighting the importance of MVPA.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"15 ","pages":"1465168"},"PeriodicalIF":3.2000,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659758/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fphys.2024.1465168","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: This study aimed to determine the associations between different intensities of moderate to vigorous physical activity (MVPA) and the incidence of chronic diseases, and to assess the risk levels associated with these activities over time.

Methods: A prospective cohort study (UK Biobank Activity Project) with data collected between June 2013 and December 2015 included 59,896 adults (mean age = 59.68; male = 38.03%) free from chronic diseases. Participants were categorized into tertiles based on their weekly MVPA: lowest (<224 min for males, <143 min for females), medium (224-444 min for males, 143-308 min for females), and highest (≥444 min for males, ≥308 min for females), stratified by gender. The mean onset of chronic disease symptoms occurred at 3.57 years, with participants followed up during this period. Wearable accelerometry data were used to quantify MVPA levels.

Findings: Lowest tertile of MVPA were significantly correlated with increased risks of chronic disease (24%-110% increased risk) based on odds ratios (ORs), with dose-response relationship observed. In males with the lowest tertile of MVPA, significant associations were identified with type 2 diabetes mellitus (T2DM) (OR = 1.90; CI: 1.44-2.51), neurodegenerative disease (OR = 1.80; CI: 1.19-2.71), metabolic syndrome (OR = 1.34; CI: 1.18-1.53), hypertension (OR = 1.27; CI: 1.12-1.44), and atherosclerotic cardiovascular disease (ASCVD) (OR = 1.24; CI: 1.03-1.49). In females, the lowest tertile of MVPA levels were associated with increased risks of neurodegenerative disease (OR = 2.10; CI: 1.36-3.24), T2DM (OR = 1.88; CI: 1.37-2.58), cerebrovascular disease (OR = 1.61; CI: 1.12-2.29), ASCVD (OR = 1.58; CI: 1.23-2.03), metabolic syndrome (OR = 1.49; CI: 1.32-1.69), and hypertension (OR = 1.44; CI: 1.29-1.61). Longitudinally, the lowest tertile of MVPA in males showed elevated risks for neurodegenerative disease (HR = 2.13; CI: 1.24-3.66), T2DM (HR = 1.83; CI: 1.30-2.57), hypertension (HR = 1.33; CI: 1.15-1.53), metabolic syndrome (HR = 1.32; CI: 1.14-1.54), and ASCVD (HR = 1.29; CI: 1.03-1.61). In females, the lowest tertile of MVPA was associated with similar risks for ASCVD (HR = 1.59; CI: 1.16-2.20), T2DM (HR = 1.57; CI: 1.08-2.29), hypertension (HR = 1.53; CI: 1.34-1.74), and metabolic syndrome (HR = 1.50; CI: 1.29-1.73).

Conclusion: Using wearable accelerometry data, this study demonstrated the quantifiable risks of chronic diseases and their development, highlighting the importance of MVPA.

成人和老年人中高强度体育活动与慢性疾病风险之间的关联:来自英国生物银行研究的见解
背景:本研究旨在确定不同强度的中高强度体育活动(MVPA)与慢性疾病发病率之间的关系,并评估与这些活动相关的风险水平。方法:一项前瞻性队列研究(英国生物银行活动项目),数据收集于2013年6月至2015年12月,包括59,896名成年人(平均年龄= 59.68;男性= 38.03%)无慢性疾病。参与者根据每周MVPA分为最低(研究结果:MVPA的最低分位数与慢性疾病风险增加显著相关(风险增加24%-110%),基于优势比(ORs),观察到剂量-反应关系。MVPA不育值最低的男性与2型糖尿病(T2DM)有显著相关性(OR = 1.90;CI: 1.44-2.51),神经退行性疾病(OR = 1.80;CI: 1.19-2.71),代谢综合征(OR = 1.34;CI: 1.18-1.53),高血压(OR = 1.27;CI: 1.12-1.44)和动脉粥样硬化性心血管疾病(ASCVD) (OR = 1.24;置信区间:1.03—-1.49)。在女性中,最低的MVPA水平与神经退行性疾病的风险增加相关(OR = 2.10;Ci: 1.36-3.24), t2dm (or = 1.88;CI: 1.37-2.58)、脑血管疾病(OR = 1.61;Ci: 1.12-2.29), ascvd (or = 1.58;CI: 1.23-2.03),代谢综合征(OR = 1.49;CI: 1.32-1.69)和高血压(OR = 1.44;置信区间:1.29—-1.61)。纵向上,MVPA水平最低的男性患神经退行性疾病的风险较高(HR = 2.13;Ci: 1.24-3.66), t2dm (hr = 1.83;CI: 1.30-2.57),高血压(HR = 1.33;CI: 1.15-1.53),代谢综合征(HR = 1.32;CI: 1.14-1.54)和ASCVD (HR = 1.29;置信区间:1.03—-1.61)。在女性中,最低的MVPA与ASCVD的相似风险相关(HR = 1.59;Ci: 1.16-2.20), t2dm (hr = 1.57;CI: 1.08-2.29),高血压(HR = 1.53;CI: 1.34-1.74)和代谢综合征(HR = 1.50;置信区间:1.29—-1.73)。结论:利用可穿戴加速度计数据,本研究证明了慢性疾病及其发展的可量化风险,强调了MVPA的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.50
自引率
5.00%
发文量
2608
审稿时长
14 weeks
期刊介绍: Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信