Óscar Martínez-González , M. Ángeles Alonso-Fernández , Mónica García-Alonso , Blanca López-Matamala , Susana Soto-Fernández , Carmen Martín-Parra , Elena Marín-Alcolado , Miriam Chana-García , M. José Perez-Grueso , Madian Manso-Álvarez , María de Lucas-Gallego , Ángela Algaba-Calderón , Rafael Blancas
{"title":"Deep sedation for gastrointestinal endoscopy in elderly patients. Subgroup analysis","authors":"Óscar Martínez-González , M. Ángeles Alonso-Fernández , Mónica García-Alonso , Blanca López-Matamala , Susana Soto-Fernández , Carmen Martín-Parra , Elena Marín-Alcolado , Miriam Chana-García , M. José Perez-Grueso , Madian Manso-Álvarez , María de Lucas-Gallego , Ángela Algaba-Calderón , Rafael Blancas","doi":"10.1016/j.dld.2024.11.029","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Gastrointestinal endoscopy is increasingly performed under sedation in older patients. Aging has implications in increasing the morbidity and the risk of complications related to sedation. The aim of this study is to assess the difference in complications between patients aged 65 to 74 years and those aged over 75 years.</div></div><div><h3>Materials and methods</h3><div>A prospective study was designed. Patients older than 65 years under deep sedation were included. Multivariate analysis was performed to assess complications in the propofol-sedated gastroscopy and propofol- and fentanyl-sedated colonoscopy groups.</div></div><div><h3>Results</h3><div>1,225 sedations were performed and 97.3 % of endoscopic procedures were completed. Desaturation occurred in 121 patients (9.9 %) with no significant differences between the two groups, 71 patients in the 65–74 age group and 50 in the ≥75 age group (9.2 % vs 10.9 %; <em>p</em> = 0.336). Major complications requiring intervention occurred in 68 patients (5.6 %), 46 in the 65–74 age group and 22 in the ≥75 age group (6.0 % vs 4.8 %; <em>p</em> = 0.385). Age contributed to the development of complications in gastroscopy under propofol sedation.</div></div><div><h3>Conclusions</h3><div>Complications of gastrointestinal endoscopy under deep sedation in patients older than 65 years are mostly not serious. Deep sedation in patients aged 75 years and older is not associated with more complications than in patients aged 65 to 74 years.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1266-1272"},"PeriodicalIF":4.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive and Liver Disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1590865824011204","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Gastrointestinal endoscopy is increasingly performed under sedation in older patients. Aging has implications in increasing the morbidity and the risk of complications related to sedation. The aim of this study is to assess the difference in complications between patients aged 65 to 74 years and those aged over 75 years.
Materials and methods
A prospective study was designed. Patients older than 65 years under deep sedation were included. Multivariate analysis was performed to assess complications in the propofol-sedated gastroscopy and propofol- and fentanyl-sedated colonoscopy groups.
Results
1,225 sedations were performed and 97.3 % of endoscopic procedures were completed. Desaturation occurred in 121 patients (9.9 %) with no significant differences between the two groups, 71 patients in the 65–74 age group and 50 in the ≥75 age group (9.2 % vs 10.9 %; p = 0.336). Major complications requiring intervention occurred in 68 patients (5.6 %), 46 in the 65–74 age group and 22 in the ≥75 age group (6.0 % vs 4.8 %; p = 0.385). Age contributed to the development of complications in gastroscopy under propofol sedation.
Conclusions
Complications of gastrointestinal endoscopy under deep sedation in patients older than 65 years are mostly not serious. Deep sedation in patients aged 75 years and older is not associated with more complications than in patients aged 65 to 74 years.
期刊介绍:
Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD).
Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology.
Contributions consist of:
Original Papers
Correspondence to the Editor
Editorials, Reviews and Special Articles
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Symposia and Mini-symposia.