Deep sedation for gastrointestinal endoscopy in elderly patients. Subgroup analysis

IF 4 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Óscar Martínez-González , M. Ángeles Alonso-Fernández , Mónica García-Alonso , Blanca López-Matamala , Susana Soto-Fernández , Carmen Martín-Parra , Elena Marín-Alcolado , Miriam Chana-García , M. José Perez-Grueso , Madian Manso-Álvarez , María de Lucas-Gallego , Ángela Algaba-Calderón , Rafael Blancas
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引用次数: 0

Abstract

Background

Gastrointestinal endoscopy is increasingly performed under sedation in older patients. Aging has implications in increasing the morbidity and the risk of complications related to sedation. The aim of this study is to assess the difference in complications between patients aged 65 to 74 years and those aged over 75 years.

Materials and methods

A prospective study was designed. Patients older than 65 years under deep sedation were included. Multivariate analysis was performed to assess complications in the propofol-sedated gastroscopy and propofol- and fentanyl-sedated colonoscopy groups.

Results

1,225 sedations were performed and 97.3 % of endoscopic procedures were completed. Desaturation occurred in 121 patients (9.9 %) with no significant differences between the two groups, 71 patients in the 65–74 age group and 50 in the ≥75 age group (9.2 % vs 10.9 %; p = 0.336). Major complications requiring intervention occurred in 68 patients (5.6 %), 46 in the 65–74 age group and 22 in the ≥75 age group (6.0 % vs 4.8 %; p = 0.385). Age contributed to the development of complications in gastroscopy under propofol sedation.

Conclusions

Complications of gastrointestinal endoscopy under deep sedation in patients older than 65 years are mostly not serious. Deep sedation in patients aged 75 years and older is not associated with more complications than in patients aged 65 to 74 years.
深度镇静用于老年患者胃肠内镜检查。亚组分析。
背景:越来越多的老年患者在镇静状态下进行胃肠内镜检查。衰老会增加与镇静相关的发病率和并发症的风险。本研究的目的是评估65 - 74岁患者和75岁以上患者并发症的差异。材料与方法:设计前瞻性研究。年龄大于65岁的患者接受深度镇静治疗。采用多变量分析来评估异丙酚镇静胃镜组和异丙酚和芬太尼镇静结肠镜组的并发症。结果:共进行了1225次镇静,97.3%的内镜手术完成。121例(9.9%)患者发生了去饱和,两组间无显著差异,65-74岁年龄组71例,≥75岁年龄组50例(9.2% vs 10.9%;P = 0.336)。68例(5.6%)患者出现了需要干预的主要并发症,其中65-74岁组46例,≥75岁组22例(6.0% vs 4.8%;P = 0.385)。年龄对异丙酚镇静下胃镜检查并发症的发生有影响。结论:65岁以上患者深度镇静下胃肠内镜并发症多不严重。75岁及以上患者的深度镇静与65至74岁患者的并发症无关。
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来源期刊
Digestive and Liver Disease
Digestive and Liver Disease 医学-胃肠肝病学
CiteScore
6.10
自引率
2.20%
发文量
632
审稿时长
19 days
期刊介绍: Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.
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