Unveiling the Mechanism of Retinoic Acid Therapy for Cutaneous Warts: Insights from Multi-Omics Integration.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-12-18 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S504391

Zi-Yue Dong, Ming-Jie He, Yuan Hu, Fang Wang, De-Long Ran, De-Shuang Fu, Qing He, Run-Ping Yang, Jiang-An Zhang

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引用次数: 0

Abstract

Background: Due to limited treatment options, cutaneous warts caused by human papillomavirus (HPV) remain a significant clinical challenge. Furthermore, the genetic susceptibility and molecular basis of viral warts are not yet fully understood.

Methods: We utilized a multi-omics integration approach, encompassing genome-wide association study (GWAS) meta-analysis, summary data-based Mendelian randomization (SMR) analysis, and transcriptomic validation using the GSE136347 dataset. Differential gene expression (DEG) analysis was conducted to identify significant changes in gene expression between wart tissues and healthy skin.

Results: Our analyses revealed five genetic susceptibility genes associated with cutaneous warts, with RARA showing significant differential expression in wart tissues. Co-expression analysis indicated that RARA may regulate apoptosis through interactions with BAX, a pro-apoptotic gene. Additionally, functional annotation via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses highlighted key biological processes and pathways involved in wart pathogenesis.

Conclusion: This study identifies RARA as a pivotal regulator in the molecular pathology of cutaneous warts and a promising therapeutic target. RA-based therapies could offer effective and less invasive alternatives for wart treatment. Future investigations should refine the molecular role of RARA to optimize clinical interventions.

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揭示维甲酸治疗皮肤疣的机制：来自多组学整合的见解。

背景：由于治疗选择有限，由人乳头瘤病毒（HPV）引起的皮肤疣仍然是一个重大的临床挑战。此外，病毒疣的遗传易感性和分子基础尚未完全了解。方法：采用多组学整合方法，包括全基因组关联研究（GWAS）荟萃分析，基于汇总数据的孟德尔随机化（SMR）分析，以及使用GSE136347数据集的转录组学验证。进行差异基因表达（DEG）分析，以确定疣组织和健康皮肤之间基因表达的显著变化。结果：我们的分析揭示了5个与皮肤疣相关的遗传易感基因，其中RARA在疣组织中表现出显著的差异表达。共表达分析表明，RARA可能通过与促凋亡基因BAX的相互作用调控细胞凋亡。此外，通过基因本体（GO）和京都基因与基因组百科全书（KEGG）途径分析的功能注释突出了涉及疣发病的关键生物学过程和途径。结论：本研究确定了RARA在皮肤疣的分子病理学中是一个关键的调节因子，也是一个有希望的治疗靶点。基于ra的疗法可以为疣治疗提供有效且侵入性较小的替代方法。未来的研究应细化RARA的分子作用，以优化临床干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.