Asymmetrical patterns of β-amyloid deposition and cognitive changes in Alzheimer's disease: the SILCODE study.

IF 2.9 2区医学 Q2 NEUROSCIENCES

Cerebral cortex Pub Date : 2024-12-03 DOI:10.1093/cercor/bhae485

Xianfeng Yu, Ying Zhang, Yue Cai, Ning Rong, Ruixian Li, Rong Shi, Min Wei, Jiehui Jiang, Ying Han

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Abstract

The asymmetric pattern of β-amyloid plaque distribution across Alzheimer's disease clinical progression stages remains unclear. In this study, 66 participants with normal cognition, 59 with subjective cognitive decline, 12 with mild cognitive impairment, and 11 with Alzheimer's disease dementia were included in the Sino Longitudinal Study on Cognitive Decline (SILCODE) cohort. A regional asymmetry index, denoting the left-right asymmetry of β-amyloid plaques, was derived for each region based on the Anatomical Automatic Labeling atlas. The level of β-amyloid plaques in each region was compared among different clinical stages of Alzheimer's disease using the analysis of variance. An additional correlation analysis examined the relationship between each region of interest's cognitive performance scores and asymmetry index values. We found that β-amyloid appears to be lateralized in different stages of Alzheimer's disease. In addition, there is a significant correlation between β-amyloid asymmetry in various brain regions and cognition. The observed Aβ lateralization could potentially be utilized as a neuroimaging biomarker throughout AD progression.

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.