Seasonal Variations in Triptan Prescription in Japan: A Nationwide Time-Series Analysis

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2024-12-22 DOI:10.1002/brb3.70184

Muneto Tatsumoto, Koichi Hirata, Takeo Nakayama, Kentaro Yamato, Hiromi Sano, Lyo Inuyama

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引用次数: 0

Abstract

Objective

This study aimed to investigate seasonal differences in migraine onset in Japan and associated trends in the prescription of triptan.

Background

The relationship between seasonal changes and the onset of migraine remains largely unknown.

Methods

We combined the large-scale medical claims data in Japan with city-level meteorological data presented by the Japan Weather Association. The study period was from January 2018 to December 2019. We included patients aged 18–74 years and diagnosed with migraine who had been prescribed triptans in 2018. Patients were categorized into four groups according to the seasons when they were prescribed medicines: winter (January–March), spring (April–June), summer (July–September), and autumn (October–December). Migraine onsets were defined by the time of triptan prescription. The least-square mean differences between the seasons were estimated with linear mixed-effects models for repeated measures, adjusting for the following covariates: sex, age, acute migraine medications, and medications for migraine prevention, comorbidities that can induce migraine, other comorbidities, and the estimated age of menopause in females.

Results

We analyzed data of 12,986 patients in 2019 after triptan had been prescribed (female 74.1%). The mean age was 44.1 years. The mean number of amounts of prescriptions comprised 2.12 tablets/month in spring and summer, whereas there were only 2.09 tablets/month in autumn and 2.00 tablets/month in winter. The amount of triptan prescribed in winter was lower than in spring (β = −0.117; 95% confidence interval [CI]: −0.169 to −0.065).

Conclusion

The study results suggest that seasons can have an impact on the onset of migraine; thus, clinicians may advise patients to take preventive actions, including self-care and drug therapies, from the winter stage. This should be done in order to reduce the number of migraine onsets in high-risk season (spring) regardless of region.

Abstract Image

查看原文本刊更多论文

曲坦类药物处方在日本的季节性变化：一个全国性的时间序列分析。

目的：本研究旨在调查日本偏头痛发作的季节性差异以及曲坦类药物处方的相关趋势。背景：季节变化与偏头痛发病之间的关系在很大程度上仍然未知。方法：将日本大规模医疗理赔数据与日本气象协会提供的市级气象数据相结合。研究期间为2018年1月至2019年12月。我们纳入了2018年服用曲坦类药物的18-74岁偏头痛患者。将患者按用药季节分为冬季（1 - 3月）、春季（4 - 6月）、夏季（7 - 9月）、秋季（10 - 12月）四组。偏头痛发作的定义是曲坦类药物处方的时间。使用重复测量的线性混合效应模型估计季节之间的最小二乘平均差异，调整以下协变量：性别、年龄、急性偏头痛药物、偏头痛预防药物、可诱发偏头痛的合并症、其他合并症和女性绝经的估计年龄。结果：我们分析了2019年服用曲坦类药物后12986例患者的数据，其中女性占74.1%。平均年龄为44.1岁。春、夏季平均处方量为2.12片/月，秋季为2.09片/月，冬季为2.00片/月。冬季曲坦类药物用量低于春季(β = -0.117；95%置信区间[CI]: -0.169 ~ -0.065)。结论：研究结果表明，季节对偏头痛的发病有影响；因此，临床医生可能会建议患者从冬季开始采取预防措施，包括自我保健和药物治疗。这样做是为了减少在高危季节（春季）偏头痛发作的数量，无论在哪个地区。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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