Small-Molecule Fluorescent Probes for Butyrylcholinesterase.

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2024-12-23 DOI:10.1002/cmdc.202400875

Zibo Lin, Yuanyuan Liao, Donglei Tian, Junyu Liao, Qiong Chen, Jun Yin

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引用次数: 0

Abstract

Butyrylcholinesterase plays an indispensable role in organisms, and its abnormal expression poses a significant threat to human health and safety, covering various aspects including liver-related diseases, diabetes, obesity, cardiovascular and cerebrovascular diseases, and neurodegenerative diseases. In addition, toxic substances such as organophosphorus and carbamate pesticides markedly inhibit BChE activity. BChE activity serves as a critical parameter for the clinical diagnosis of acute organophosphorus pesticide poisoning and the evaluation of organophosphorus and carbamate pesticide residues. Therefore, the accurate and reliable detection of butyrylcholinesterase activity is particularly urgent and important for in-depth analysis of its biological function, diagnosis and therapy of related diseases, drug screening and sensitive detection of pesticide residues. Fluorescent probes have become a promising tool for sensing and imaging of butyrylcholinesterase, due to its advantages of high spatio-temporal resolution, high selectivity, non-invasive, high sensitivity, and tailored molecule structures. Here, this paper provides a comprehensive overview of the research progress in the sensing, imaging and therapy of butyrylcholinesterase utilizing fluorescent probes. This paper might be a useful guideline for researchers to design new high-performance fluorescence probes for BChE, and making further contributions to this intriguing field.

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丁基胆碱酯酶的小分子荧光探针。

丁基胆碱酯酶在生物体中发挥着不可或缺的作用，其异常表达对人类健康和安全构成重大威胁，涉及肝脏相关疾病、糖尿病、肥胖、心脑血管疾病、神经退行性疾病等各个方面。此外，有机磷和氨基甲酸酯类农药等有毒物质显著抑制BChE活性。BChE活性是临床诊断急性有机磷农药中毒、评价有机磷和氨基甲酸酯类农药残留的重要指标。因此，准确、可靠地检测丁基胆碱酯酶活性，对于深入分析其生物学功能、相关疾病的诊断和治疗、药物筛选和农药残留的灵敏检测都显得尤为迫切和重要。荧光探针具有高时空分辨率、高选择性、无创、高灵敏度和分子结构定制等优点，已成为丁基胆碱酯酶检测和成像的重要工具。本文就利用荧光探针检测、成像和治疗丁基胆碱酯酶的研究进展作一综述。本文为研究人员设计新型高效的BChE荧光探针提供了有益的指导，并为这一有趣的领域做出了进一步的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.