Li Zhao, Tianjian Sha, Yufu Liu, Qingsong Mei*, Haibin Li, Pinghua Sun, Haibo Zhou* and Huaihong Cai*,
{"title":"Rapid and Large-Scale Synthesis of Chiral and Fluorescent Sulfur Quantum Dots for Intracellular Temperature Monitoring","authors":"Li Zhao, Tianjian Sha, Yufu Liu, Qingsong Mei*, Haibin Li, Pinghua Sun, Haibo Zhou* and Huaihong Cai*, ","doi":"10.1021/cbmi.4c0005210.1021/cbmi.4c00052","DOIUrl":null,"url":null,"abstract":"<p >The large-scale preparation of fluorescent nanomaterials with laboratory-relevant chemical and optical properties will greatly forward their consumer market applications; however, it still remains challenging. In this work, a universal strategy was developed for the rapid and large-scale synthesis of fluorescent sulfur quantum dots that recently has drawn great attention because of their unique optical characteristics. From the fact that empty 3d orbitals of sulfide species are able to bind with lone-pair π electrons of the heteroatomic groups, many amino-group containing compounds, such as amino acid and polyethylenimine molecules, were exploited to synthesize sulfur quantum dots. This 10 min preparation period endowed sulfur quantum dots with bright blue fluorescence and also chirality. Due to the user-friendly and rapid operation, this strategy can be extended to the large-scale synthesis of sulfur quantum dots with a yield of 16.844 g for one batch of experiment. Moreover, it was found that the sulfur quantum dots exhibited a reversible temperature-dependent luminescent property with a sensitivity of 0.72%/°C, which showed excellent intracellular temperature monitoring capability for inflammation-related disease diagnostics.</p>","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"2 12","pages":"817–824 817–824"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbmi.4c00052","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical & Biomedical Imaging","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/cbmi.4c00052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The large-scale preparation of fluorescent nanomaterials with laboratory-relevant chemical and optical properties will greatly forward their consumer market applications; however, it still remains challenging. In this work, a universal strategy was developed for the rapid and large-scale synthesis of fluorescent sulfur quantum dots that recently has drawn great attention because of their unique optical characteristics. From the fact that empty 3d orbitals of sulfide species are able to bind with lone-pair π electrons of the heteroatomic groups, many amino-group containing compounds, such as amino acid and polyethylenimine molecules, were exploited to synthesize sulfur quantum dots. This 10 min preparation period endowed sulfur quantum dots with bright blue fluorescence and also chirality. Due to the user-friendly and rapid operation, this strategy can be extended to the large-scale synthesis of sulfur quantum dots with a yield of 16.844 g for one batch of experiment. Moreover, it was found that the sulfur quantum dots exhibited a reversible temperature-dependent luminescent property with a sensitivity of 0.72%/°C, which showed excellent intracellular temperature monitoring capability for inflammation-related disease diagnostics.
期刊介绍:
Chemical & Biomedical Imaging is a peer-reviewed open access journal devoted to the publication of cutting-edge research papers on all aspects of chemical and biomedical imaging. This interdisciplinary field sits at the intersection of chemistry physics biology materials engineering and medicine. The journal aims to bring together researchers from across these disciplines to address cutting-edge challenges of fundamental research and applications.Topics of particular interest include but are not limited to:Imaging of processes and reactionsImaging of nanoscale microscale and mesoscale materialsImaging of biological interactions and interfacesSingle-molecule and cellular imagingWhole-organ and whole-body imagingMolecular imaging probes and contrast agentsBioluminescence chemiluminescence and electrochemiluminescence imagingNanophotonics and imagingChemical tools for new imaging modalitiesChemical and imaging techniques in diagnosis and therapyImaging-guided drug deliveryAI and machine learning assisted imaging