Electrochemical Alkoxylation of Benzylic C(sp3)−H Bonds

Abstract

We report an electrochemical process for the direct alkoxylation of benzylic C(sp³)−H bonds without the need for external oxidants or metal catalysts. This environmentally friendly and sustainable synthetic strategy facilitates the alkoxylation of C(sp³)−H in benzylic groups. The approach enables the late‐stage incorporation of complex alkoxy groups into bioactive molecules, providing potential applications in the synthesis of celestolide derivatives.