HClO-Activated Near-Infrared Chemiluminescent Probes with a Malononitrile Group for In-Vivo Imaging

IF 27.4 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Yalei Cao, Juqing Gu, Zhijian Chen, Jucai Gao, Jie Yang, Wenbo Wu, Manman Fang, Qianqian Li, Bin Liu, Zhen Li
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Abstract

Chemiluminescence (CL) imaging has emerged as a powerful approach to molecular imaging that allows exceptional sensitivity with virtually no background interference because of its unique capacity to emit photons without an external excitation source. Despite its high potential, the application of this nascent technique faces challenges because the current chemiluminescent agents have limited reactive sites, require complex synthesis, are insufficiently bright, and lack near-infrared emission. Herein, a series of HClO-activated chemiluminescent probes that exhibit robust near-infrared emission are studied. Specifically engineered to respond to HClO, a known biomarker of acute inflammation, these probes achieve high-contrast in vivo imaging by eliminating the need for constant external excitation. Comprehensive experimental and theoretical investigations demonstrate that the CL of the probes depends on the reactivity of the vinylene bonds, following a concerted decomposition of the oxidized chemiluminescent molecule. The application of these chemiluminescent nanoparticles in vivo facilitates high-contrast imaging of acute inflammation, providing real-time, high-contrast visualization of inflammatory conditions. This advancement signifies a leap forward for chemiluminescent nanoplatforms in biomedical imaging and expands the available methodologies in this field.

Abstract Image

含丙二腈基团的hcl激活近红外化学发光探针用于体内成像
化学发光(CL)成像已经成为一种强大的分子成像方法,它具有极高的灵敏度,几乎没有背景干扰,因为它具有独特的能力,可以在没有外部激发源的情况下发射光子。尽管具有很高的潜力,但这种新兴技术的应用面临着挑战,因为目前的化学发光剂具有有限的反应位点,需要复杂的合成,亮度不够,缺乏近红外发射。本文研究了一系列具有强近红外发射能力的hcl激活化学发光探针。这些探针专门设计用于响应HClO(一种已知的急性炎症生物标志物),通过消除持续外部刺激的需要,实现高对比度的体内成像。综合实验和理论研究表明,探针的CL取决于氧化化学发光分子协同分解后乙烯键的反应活性。这些化学发光纳米颗粒在体内的应用促进了急性炎症的高对比度成像,提供了炎症状况的实时、高对比度可视化。这一进展标志着化学发光纳米平台在生物医学成像领域的飞跃,并扩展了该领域的可用方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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