Predesign of Covalent‐Organic Frameworks for Efficient Photocatalytic Dehydrogenative Cross‐Coupling Reaction

Abstract

The dehydrogenative cross‐coupling reaction is the premier route for synthesizing important 4‐quinazolinone drugs. However, it usually requires high reaction temperature and long reaction time, and the yield of the final product is low. Here two stable and photosensitive covalent‐organic frameworks (COFs), TAPP‐An and TAPP‐Cu‐An are purposefully designed and constructed to serve as unprecedented heterogeneous tandem catalysts to complete dehydrogenative cross‐coupling reactions in a short time and under mild reaction conditions (room temperature and light), leading to the high‐efficient photosynthesis of 4‐quinazolinones. Particularly, TAPP‐Cu‐An is the best heterogeneous catalyst currently available for the synthesis of 4‐quinazolinones, even surpassing all the catalysts reported so far. It also enables one‐step photosynthesis of 4‐quinazolinones with higher conversion (>99%) and selectivity (>99%) in a shorter time, and the product can be easily prepared on a gram scale. Extensive experiments combined with theoretical calculations show that the excellent photogenerated charge separation and transport capability, as well as the synergistic An‐Cu catalysis in TAPP‐Cu‐An are the main driving forces for this efficient reaction.