Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis

IF 13 1区 医学 Q1 CLINICAL NEUROLOGY
Mohammad Khalafi, William J. Dartora, Laura Beth J. McIntire, Tracy A. Butler, Krista M. Wartchow, Seyed Hani Hojjati, Qolamreza R. Razlighi, Kiarash Shirbandi, Liangdong Zhou, Kewei Chen, Ke Xi, Samprit Banerjee, Nancy Foldi, Silky Pahlajani, Lidia Glodzik, Yi Li, Mony J. de Leon, Gloria C. Chiang
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引用次数: 0

Abstract

Our review summarizes the diagnostic accuracy of plasma and cerebrospinal fluid (CSF) phosphorylated tau 217 (p-tau217) in detecting amyloid and tau pathology on positron emission tomography (PET). We systematically reviewed studies that reported the diagnostic accuracy of plasma and CSF p-tau217, searching MEDLINE/PubMed, Scopus, and Web of Science through August 2024. The accuracy of p-tau217 in predicting amyloid and tau pathology on PET was evaluated in 30 studies. Both plasma and CSF p-tau217 effectively detect amyloid and tau PET deposition. Plasma p-tau217 showed 82% sensitivity for detecting amyloid and 83% for tau, with 86% and 83% specificity, respectively. CSF p-tau217 had 79% sensitivity for amyloid and 91% for tau, with 91% and 84% specificity. p-tau217 effectively identifies Alzheimer's disease (AD) pathology. Plasma p-tau217 was comparable to CSF p-tau217 in detecting amyloid deposition on PET. Despite being less sensitive for detecting tau deposition on PET, plasma p-tau217 can be an efficient screening tool for underlying AD pathology.

Highlights

  • Plasma phosphorylated tau 217 (p-tau217) serves as a viable biomarker alternative to cerebrospinal fluid p-tau217 due to the strong concordance between their results.
  • Plasma p-tau217 accurately identifies amyloid and tau positron emission tomography (PET) positivity, exhibiting a low rate of false negatives and positives, thereby establishing it as a reliable diagnostic tool for Alzheimer's disease (AD).
  • Plasma p-tau217 demonstrates slightly higher accuracy in predicting amyloid PET positivity compared to tau PET positivity.
  • Plasma p-tau217 demonstrates higher predictive accuracy in detecting AD pathology among cognitively impaired individuals, compared to cognitively unimpaired individuals, suggesting its enhanced utility as a diagnostic biomarker in clinical settings.

Abstract Image

磷酸化tau217在检测认知受损和未受损的阿尔茨海默病病理中的诊断准确性:一项系统综述和荟萃分析
本文综述了血浆和脑脊液(CSF)磷酸化tau217 (p-tau217)在正电子发射断层扫描(PET)检测淀粉样蛋白和tau病理中的诊断准确性。我们系统回顾了报道血浆和脑脊液p-tau217诊断准确性的研究,检索了MEDLINE/PubMed, Scopus和Web of Science,截止到2024年8月。在30项研究中评估了p-tau217在PET上预测淀粉样蛋白和tau病理的准确性。血浆和脑脊液p-tau217均可有效检测淀粉样蛋白和tau PET沉积。血浆p-tau217检测淀粉样蛋白的敏感性为82%,tau蛋白的敏感性为83%,特异性分别为86%和83%。CSF p-tau217对淀粉样蛋白的敏感性为79%,对tau蛋白的敏感性为91%,特异性为91%和84%。p-tau217有效识别阿尔茨海默病(AD)病理。血浆p-tau217在PET检测淀粉样蛋白沉积方面与CSF p-tau217相当。尽管血浆p-tau217对检测PET上的tau沉积不太敏感,但它可以作为潜在AD病理的有效筛查工具。
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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