HPV vaccination and anal HPV infection in gay, bisexual, and other men who have sex with men

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-01-25 DOI:10.1016/j.vaccine.2024.126644

Pareesa Kassam , Mariam El-Zein , Joseph E. Tota , Pierre-Paul Tellier , François Coutlée , Alexandra de Pokomandy , Eduardo L. Franco

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引用次数: 0

Abstract

Background

Gay, bisexual, and other men who have sex with men (gbMSM) have a higher risk of human papillomavirus (HPV) infection and related diseases and would benefit from preventive measures such as HPV vaccination. We assessed the association between HPV vaccination and anal HPV infection in HIV-negative gbMSM and gbMSM living with HIV from the Lubricant Investigation in Men to Inhibit Transmission of HPV Infection study.

Methods

Participants attended 7 visits over 12 months where they provided a nurse-collected anal sample and self-completed a questionnaire on risk factors and HPV vaccination. Samples were tested for HPV using polymerase chain reaction assays. We assessed the association with HPV vaccination and anal HPV prevalence and incidence using logistic and Cox regression, respectively. Analyses at the individual- (unit of analysis = participant) and HPV-level (unit of analysis = HPV type) considered vaccine-targeted types (any of HPVs 6/11/16/18) as the outcome. To assess construct validity, we repeated analyses considering incidence of non-vaccine-targeted (within- and cross-species) HPV types at the HPV-level. Estimates were adjusted for a propensity score to predict cumulative HPV positivity based on selected study and participant characteristics.

Results

Of 258 enrolled participants (18.2–71.7 years; 69 being HIV-positive), 23.3 % were vaccinated at baseline. At the individual-level, there was no association between vaccination and HPVs 6/11/16/18 prevalence (n = 250, aOR = 1.12, 95 % CI = 0.56–2.22) or incidence (n = 152, aHR = 0.34, 95 % CI = 2.19 × 10⁻¹⁸-1.38). At the HPV-level, while there was no association with HPVs 6/11/16/18 prevalence (n = 1000, aOR = 0.99, 95 % CI = 0.57–1.71), vaccination was associated with a reduction in HPVs 6/11/16/18 incidence (n = 754, aHR = 0.22, 95 % CI = 6.01 × 10⁻¹⁸-0.79). Vaccination was not associated with incidence of within-species (n = 2299, aHR = 0.76, CI = 0.42–1.24) or cross-species (n = 3774, aHR = 1.28, CI = 0.89–1.85) HPV types. Results were similar by HIV status.

Conclusion

Our findings support that HPV vaccination protects against incident anal infection of vaccine-targeted HPV types, thus, gbMSM should be encouraged to get vaccinated against HPV.

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男同性恋、双性恋和其他男男性行为者的HPV疫苗接种和肛门HPV感染。

背景：男同性恋、双性恋和其他男男性行为者（gbMSM）感染人乳头瘤病毒（HPV）及相关疾病的风险较高，应采取HPV疫苗接种等预防措施。我们评估了HPV疫苗接种与HIV阴性gbMSM和感染HIV的gbMSM肛门HPV感染之间的关系，该研究来自于男性润滑剂调查以抑制HPV感染的传播。方法：参与者在12个月内进行了7次访问，提供了护士收集的肛门样本，并自行填写了一份关于危险因素和HPV疫苗接种的问卷。用聚合酶链反应法检测样本的HPV。我们分别使用logistic回归和Cox回归评估了HPV疫苗接种和肛门HPV患病率和发病率之间的关系。个体（分析单位=参与者）和HPV水平（分析单位= HPV类型）的分析考虑了疫苗靶向型（任何HPV / 6/11/16/18）作为结果。为了评估结构的有效性，我们在HPV水平上考虑了非疫苗靶向（物种内和跨物种）HPV类型的发生率。根据所选研究和参与者特征调整了预测累积HPV阳性的倾向评分。结果：258名入组参与者(18.2-71.7岁；69名艾滋病毒阳性)，23.3%的人在基线时接种了疫苗。在个体水平上，接种疫苗与hpv 6/11/16/18患病率（n = 250, aOR = 1.12, 95% CI = 0.56-2.22）或发病率（n = 152, aHR = 0.34, 95% CI = 2.19 × 10-18-1.38）无相关性。在hpv水平，接种hpv疫苗与hpv 6/11/16/18患病率无相关性（n = 1000, aOR = 0.99, 95% CI = 0.57-1.71），但接种hpv疫苗与hpv 6/11/16/18发病率降低相关（n = 754, aHR = 0.22, 95% CI = 6.01 × 10-18-0.79）。接种疫苗与种内（n = 2299, aHR = 0.76, CI = 0.42-1.24）或种间（n = 3774, aHR = 1.28, CI = 0.89-1.85） HPV型别的发病率无关。HIV感染状况的结果相似。结论：我们的研究结果支持HPV疫苗接种可以预防疫苗靶向型HPV的肛门感染，因此，应鼓励gbMSM接种HPV疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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