50 years since the concept of homeoviscous adaptation

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimie Pub Date : 2024-12-18 DOI:10.1016/j.biochi.2024.12.008

Dmitry A. Los, Anna V. Leusenko

引用次数: 0

Abstract

This mini review focuses on the phenomenon of homeoviscous adaptation (HVA). The concept, which dominated for decades, had a significant impact on membrane and lipid research. It includes the functional characterization of biological membranes and their domains, the role of lipids and fatty acids in cell metabolic control, and the characterization of fatty acid desaturases and their roles in membrane properties modulation. This hypothesis led to the discovery of a feed-back manner of desaturase expression and membrane-associated temperature sensors in bacteria.

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自自黏自适应概念出现以来已有50年。

这篇综述主要讨论了自粘适应（HVA）现象。这个概念主导了几十年，对膜和脂质研究产生了重大影响。它包括生物膜及其结构域的功能表征，脂质和脂肪酸在细胞代谢控制中的作用，脂肪酸去饱和酶的表征及其在膜特性调节中的作用。这一假设导致了细菌中去饱和酶表达和膜相关温度传感器的反馈方式的发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimie 生物-生化与分子生物学

CiteScore

7.20

自引率

2.60%

发文量

219

审稿时长

40 days

期刊介绍： Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.