Myocardial Fibrosis in Diabetic Cardiomyopathy: Mechanisms, Implications, and Therapeutic Perspectives.

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2024-12-18 DOI:10.1016/j.cpcardiol.2024.102976

Clara Elisabeth Schmidt, Hans Dietrich Müller

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引用次数: 0

Abstract

Diabetic cardiomyopathy (DCM) represents a distinct form of heart disease characterized by structural and functional alterations in the myocardium, occurring in the absence of other cardiac conditions. This review delves into the pathophysiological mechanisms underlying myocardial fibrosis in DCM, highlighting the pivotal role of fibroblast transdifferentiation into myofibroblasts. We examine the interplay between hyperglycemia, immune cell activation, and neurohumoral signaling pathways, with a particular focus on the transforming growth factor-beta (TGF-β) signaling cascade and its contributions to collagen deposition and cardiac dysfunction. Despite significant advancements in understanding the cellular and molecular mechanisms of DCM, critical gaps remain in elucidating the precise regulatory networks involved in fibroblast activation and the role of microRNAs in these processes. By providing a comprehensive overview of current knowledge, this review aims to identify potential therapeutic targets to mitigate myocardial fibrosis and improve clinical outcomes in diabetic patients. Ultimately, addressing these gaps will pave the way for novel therapeutic strategies that can enhance heart function and reduce the burden of diabetic cardiomyopathy.

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.