Prognostic significance of lymphovascular invasion in pN0 stage gastric cancer: a propensity score matching analysis.

IF 1.6 3区医学 Q2 SURGERY

BMC Surgery Pub Date : 2024-12-21 DOI:10.1186/s12893-024-02705-8

Xuguang Jiao, Yu Wang, Hao Fu, Yongning Liu, Jianjun Qu, Weihua Fu

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引用次数: 0

Abstract

Background: To explore the potential impact of lymphovascular invasion (LVI) on overall survival (OS) of pN0 stage gastric cancer (GC) after curative resection.

Methods: A total of 497 GC patients who underwent curative gastrectomy and postoperative pathology proved negative lymph node metastasis between January 2015 and December 2018 in our center were enrolled in this study. All patients were divided into two groups according to the status of LVI. Their clinical and pathological features were compared and potential prognostic factors were analyzed using the propensity score matching analysis (PSM).

Results: Ninety-nine (19.9%) patients had LVI. The presence of LVI was associated with significantly worse survival outcomes in both the overall and PSM cohorts (χ2 = 19.635, p < 0.001; χ2 = 9.367, p = 0.002). After PSM, data of 99 pairs of patients were extracted. Multivariate analysis revealed that number of examined lymph nodes (LNs), and LVI were independent predictors of OS (all p < 0.05). Following stratified analysis, patients with LNs 11-25 and those without LVI tended to have better OS than those with LVI (LNs 11-15: χ2 = 5.019, p = 0.025; LNs 16-25: χ2 = 11.876, p = 0.001).

Conclusions: pN0 stage GC patients with LVI have poor prognosis. More than 15 lymph nodes need to be dissected to reduce the influence of LVI on the prognosis of pN0 stage GC patients.

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pN0期胃癌淋巴血管浸润的预后意义：倾向评分匹配分析。

背景：探讨淋巴血管侵袭（LVI）对pN0期胃癌根治性切除后总生存（OS）的潜在影响。方法：选取2015年1月至2018年12月在我中心行根治性胃切除术，术后病理证实淋巴结转移阴性的胃癌患者497例。所有患者根据LVI状态分为两组。采用倾向评分匹配分析（PSM）比较两组患者的临床和病理特征，并分析潜在的预后因素。结果：99例（19.9%）患者有LVI。在总体组和PSM组中，LVI的存在与较差的生存结果相关（χ2 = 19.635, p）。为减少LVI对pN0期GC患者预后的影响，需清扫15个以上淋巴结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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