Screening of priority antibiotics in Fenhe River Basin based on the environmental exposure, ecological effects, and human health risk

IF 8.1 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ruimin Liu , Qingfeng Long , Yue Liu , Linfang Wang
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Abstract

Antibiotics in surface water have attracted increasing attention because of their potential threats to aquatic ecosystems and public health. Therefore, it is crucial to develop a priority antibiotic list and establish a regulatory framework for antibiotic control. Taking the Fenhe River Basin in North China as the study area, a method to rank priority antibiotics based on their environmental exposure, ecological effects, and human health risks was established. Twenty antibiotics were detected, with the highest average concentration (118.30 ng/L) of sulfonamides. Among them, azithromycin had the lowest BioWIN3 value, and its logKow value was >4, which means that it has poor biodegradability, is relatively easily adsorbed in the soil or sediment, and is persistent. Additionally, based on a survey of local species with different nutritional structures, the ecological risk thresholds of antibiotics were calculated. The results showed that quinolones had the lowest risk threshold of average value 287.23 ng/L, with a greater potential for a negative effect on the ecological environment. Based on the threshold, norfloxacin, ofloxacin, and erythromycin were identified as the pollutants of ecological risk, their peak concentrations were approximately 2.4 times, 2 times, and 9 times their risk thresholds, respectively, which mainly distributed in the middle reaches. Regarding human health risks, ciprofloxacin posed the highest health risk, with an average health risk entropy of 2.81. Finally, the calculated results of the priority rating of antibiotics showed that ciprofloxacin, enrofloxacin, erythromycin, and azithromycin were the highest-priority antibiotics and should be prioritized in risk management.

Abstract Image

基于环境暴露、生态效应和人体健康风险的汾河流域重点抗生素筛选
地表水中的抗生素因其对水生生态系统和公众健康的潜在威胁而日益引起人们的关注。因此,制定重点抗生素清单和建立抗生素控制监管框架至关重要。以华北汾河流域为研究区,建立了基于抗生素环境暴露、生态效应和人体健康风险的抗生素优先排序方法。共检出20种抗生素,其中磺胺类药物平均浓度最高,为118.30ng/L。其中,阿奇霉素的BioWIN3值最低,其logKow值为bbb40,说明其生物降解性较差,相对容易吸附在土壤或沉积物中,且具有持久性。此外,在调查不同营养结构的当地物种的基础上,计算了抗生素的生态风险阈值。结果表明,喹诺酮类药物的风险阈值最低,平均值为287.23 ng/L,对生态环境的负面影响潜力较大。根据阈值确定诺氟沙星、氧氟沙星和红霉素为生态风险污染物,其峰值浓度分别约为风险阈值的2.4倍、2倍和9倍,主要分布在中游。在人体健康风险方面,环丙沙星的健康风险最高,平均健康风险熵为2.81。最后,抗生素优先级计算结果显示,环丙沙星、恩诺沙星、红霉素和阿奇霉素是最优先的抗生素,应优先进行风险管理。
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来源期刊
Chemosphere
Chemosphere 环境科学-环境科学
CiteScore
15.80
自引率
8.00%
发文量
4975
审稿时长
3.4 months
期刊介绍: Chemosphere, being an international multidisciplinary journal, is dedicated to publishing original communications and review articles on chemicals in the environment. The scope covers a wide range of topics, including the identification, quantification, behavior, fate, toxicology, treatment, and remediation of chemicals in the bio-, hydro-, litho-, and atmosphere, ensuring the broad dissemination of research in this field.
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