Associations of gestational anxiety and depression with neonatal hair steroid levels.

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology Pub Date : 2024-12-19 DOI:10.1016/j.psyneuen.2024.107260

Arthur Chortatos, Axel Davies Vittersø, Lauri Uusitalo, Marko Lehtonen, Johanna Huotari, Seppo Auriola, Raimo Voutilainen, Katri Backman, Leea Keski-Nisula, Soili M Lehto

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引用次数: 0

Abstract

Objective: To investigate the association prenatal maternal depression and anxiety may have on the levels of neonatal hair steroids (i.e. cortisol, cortisone, and the cortisol/cortisone ratio) at birth.

Methods: Altogether, 271 mother-infant pairs derived from the Finnish Kuopio Birth Cohort Study were assessed for maternal depression and anxiety using the Edinburgh Postnatal Depression Scale (EPDS: EPDS-10 for depression, EPDS-3A for anxiety) during the first (T1) and third (T3) trimesters. The levels of cortisol and cortisone were determined from neonatal hair samples obtained at birth. Linear mixed models adjusted for sex, preterm birth, smoking during pregnancy, and gestational diabetes were used.

Results: Neither T1 nor T3 EPDS-10 predicted the levels of neonatal hair steroids. T3 EPDS-3A (p = 0.012), but not T1 EPDS-3A, was linked to reduced neonatal hair cortisol levels. Neither T1 nor T3 EPDS-3A were significant predictors of neonate cortisone levels or cortisol/cortisone ratios.

Conclusion: Prenatal maternal anxiety, but not depression, may lead to pronounced alterations in some markers of fetal stress systems. Future research should further determine whether prenatal maternal symptoms of anxiety would form an optimal intervention target in order to attenuate fetal stress responses.

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妊娠期焦虑和抑郁与新生儿毛发类固醇水平的关系。

目的：探讨产前母亲抑郁和焦虑对新生儿毛发激素（即皮质醇、可的松及皮质醇/可的松比值）水平的影响。方法：采用爱丁堡产后抑郁量表（EPDS: EPDS-10为抑郁，EPDS- 3a为焦虑）对来自芬兰库奥皮奥出生队列研究的271对母亲在妊娠第一（T1）和第三（T3）个月期间的抑郁和焦虑进行评估。皮质醇和可的松的水平是从出生时获得的新生儿毛发样本中确定的。采用线性混合模型校正性别、早产、孕期吸烟和妊娠期糖尿病。结果：T1和T3 EPDS-10均不能预测新生儿毛发激素水平。T3 EPDS-3A （p = 0.012）与新生儿毛发皮质醇水平降低有关，而T1 EPDS-3A与此无关。T1和T3 EPDS-3A均不是新生儿可的松水平或皮质醇/可的松比值的显著预测因子。结论：产前母亲焦虑，而非抑郁，可能导致胎儿应激系统的一些标志物发生明显改变。未来的研究应进一步确定产前母亲焦虑症状是否可以成为减轻胎儿应激反应的最佳干预目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.