Cryoneurolysis for phantom limb pain: a systematic review.

IF 1.4 Q4 CLINICAL NEUROLOGY
Pain management Pub Date : 2024-12-01 Epub Date: 2024-12-20 DOI:10.1080/17581869.2024.2441650
Hanna Brancaccio, Brandon Goodwin, John DesRochers, Alec Birnbaum, Uzay Cagatay, Bianna Koutsenko, Connor Flatley, Gilbert Siu
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引用次数: 0

Abstract

Aims: Phantom limb pain (PLP) is a painful sensation occurring in patients around the site of an amputation. The aim of this systematic review is to evaluate the efficacy of cryoneurolysis in the management of phantom limb pain.

Materials and methods: A systematic review was performed according to the PRISMA 2020 guidelines. An initial search yielded 200 articles from four major scientific databases (PubMed, Embase, Cochrane Library, WebOfScience). Five articles met inclusion criteria, four of which underwent additional pooled statistical analysis.

Results: Pooled analysis of the included trials revealed a cumulative Cohen's d effect size of 1.55 (95% CI [0.24, 2.87]; p = 0.02; z = 2.32) for the reduction of pain on a 10-point pain scale following cryoneurolysis intervention. The remaining article that did not meet inclusion criteria for statistical analysis was a case report that reported a reduction in pain from 9/10 to 1/10 one week following intervention.

Conclusions: The large effect size demonstrated a statistically and clinically significant improvement in patient-reported pain. Additionally, patients may be able to reduce their amount of pharmaceutical pain management with successful cryoneurolysis treatment. However, these findings are limited by the small sample size and high heterogeneity between studies. Further high-quality studies should be performed to corroborate these findings.

Protocol registration: www.crd.york.ac.uk/prospero identifier is CRD42024543085.

冷冻神经溶解治疗幻肢痛:一项系统综述。
目的:幻肢痛(PLP)是发生在患者截肢部位周围的疼痛感觉。本系统综述的目的是评价冷冻神经溶解术治疗幻肢痛的疗效。材料和方法:根据PRISMA 2020指南进行系统评价。最初的搜索从四个主要的科学数据库(PubMed, Embase, Cochrane Library, WebOfScience)中获得了200篇文章。5篇文章符合纳入标准,其中4篇进行了额外的汇总统计分析。结果:纳入试验的汇总分析显示,累积Cohen's d效应值为1.55 (95% CI [0.24, 2.87];p = 0.02;Z = 2.32),在10分制疼痛量表中,在冷冻神经松解干预后减轻疼痛。其余不符合统计分析纳入标准的文章是一份病例报告,报告干预后一周疼痛从9/10减少到1/10。结论:大效应量表明患者报告的疼痛有统计学和临床意义上的显著改善。此外,通过成功的解冻治疗,患者可能能够减少药物疼痛管理的数量。然而,这些发现受到样本量小和研究间异质性高的限制。应该进行进一步的高质量研究来证实这些发现。协议注册:www.crd.york.ac.uk/prospero标识为CRD42024543085。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pain management
Pain management CLINICAL NEUROLOGY-
CiteScore
2.90
自引率
5.90%
发文量
62
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