Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002-2022).

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2024-12-20 DOI:10.1186/s12944-024-02383-8

Ioanna Kechagia, Fotios Barkas, Evangelos Liberopoulos, Christina Chrysohoou, Petros P Sfikakis, Costas Tsioufis, Christos Pitsavos, Demosthenes Panagiotakos

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引用次数: 0

Abstract

Background: The aim of this study was to evaluate the association between simple, combined lipid biomarkers, and 20-year cumulative incidence of new type 2 diabetes mellitus (T2DM) among adults participating in the ATTICA cohort study (2002-2022).

Methods: The present analysis included data from 2000 individuals free of T2DM at baseline (age 43 ± 13 years; 51% women). Sociodemographic, anthropometric, lifestyle, clinical, and biochemical parameters were collected at baseline and follow-up examinations; combined lipid markers were evaluated.

Results: The 20-year cumulative incidence of T2DM was 26.3% (95%CI 24.4, 28.3%). All, simple and combined lipid markers were independently associated with new T2DM onset. The accuracy of simple and combined markers was approximately 75%, without any significant differences between simple and combined indices. The additive correct classification gain of lipid markers to glucose metabolism indices on 20-year new T2DM cumulative incidence varied between 0.9% for cardiometabolic index to 10.6% for LDL-cholesterol.

Conclusions: Lipid profile is associated with the long-term onset of T2DM. Evaluated through simple or combined markers, lipid profiles can be utilized for identifying and improving risk stratification in individuals at high risk for T2DM, while also enhancing the effectiveness of primary prevention measures and public health strategies.

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单纯、联合脂质标志物与20年累积2型糖尿病发病率之间的关联：ATTICA队列研究（2002-2022）

背景：本研究的目的是评估参与ATTICA队列研究（2002-2022）的成年人中简单、联合脂质生物标志物与20年新型2型糖尿病（T2DM）累积发病率之间的关系。方法：本分析包括2000名基线时无T2DM患者(年龄43±13岁；51%的女性)。在基线和随访检查中收集社会人口学、人体测量学、生活方式、临床和生化参数；评估联合脂质标志物。结果：20年T2DM累计发病率为26.3% （95%CI 24.4, 28.3%）。所有的、单一的和联合的脂质标志物与新发T2DM独立相关。单纯指标和联合指标的准确率约为75%，单纯指标和联合指标之间无显著差异。在20年新发T2DM累积发病率中，脂质标记物对糖代谢指标的加性正确分类增益从心脏代谢指数的0.9%到ldl -胆固醇的10.6%不等。结论：血脂与T2DM的长期发病有关。通过单一或联合标志物评估，脂质谱可用于识别和改善T2DM高危人群的风险分层，同时也可提高初级预防措施和公共卫生策略的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.