Causal association between metabolites and age-related macular degeneration: a bidirectional two-sample mendelian randomization study.

IF 2.7 3区生物学

Hereditas Pub Date : 2024-12-20 DOI:10.1186/s41065-024-00356-6

Zhen-Yu Liu, Hang Zhang, Xiu-Li Sun, Jian-Ying Liu

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引用次数: 0

Abstract

Background: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly population. Accumulating evidence has revealed the possible association between metabolites and AMD. This study aimed to assess the effect of plasma metabolites on AMD and its two subtypes using a bidirectional two-sample Mendelian randomization approach.

Methods: The causality between plasma metabolites and AMD was assessed by a bidirectional two-sample Mendelian randomization (MR) analysis using the genome-wide association studies (GWAS) summary statistics of 1400 genetically determined metabolites (GDMs) and AMD. For this MR analysis, inverse variance weighted (IVW) was used as the primary method, with weighted median, MR-Egger, weighted mode, and simple mode as supplementary methods to examine the causality. MR-Egger intercept, Cochran's Q, and MR-PRESSO test were employed to evaluate possible pleiotropy and heterogeneity.

Results: The results of IVW showed significant causal associations between 13 GDMs and AMD. 1-stearoyl-GPE (18:0), androstenediol (3β,17β) monosulfate, stearoyl sphingomyelin (d18:1/18:0), xylose, and X-11,850 exhibited a protective effect on AMD, while gulonate and mannonate increased the risk of AMD. 1-stearoyl-GPE (18:0) and X-11,850 exhibited protective effects on dry AMD. DHEAS, 1-stearoyl-GPE (18:0), 5α-androstan-3β,17β-diol disulfate, xylose, androstenediol (3β,17β) monosulfate, and N2-acetyl, N6, N6-dimethyllysine exhibited a protective effect on wet AMD, while succinimide, 16a-hydroxy DHEA 3-sulfate, and X-13,553 increased the risk of wet AMD. Horizontal pleiotropy and heterogeneity did not distort the causal estimates. In the reverse MR analysis, AMD reduced the androstenediol (3β,17β) monosulfate level, and increased the stearoyl sphingomyelin(d18:1/18:0) level.

Conclusion: This study supported the effect of plasma metabolites on AMD, providing novel insights for clinical diagnosis and prevention strategy.

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代谢物与年龄相关性黄斑变性之间的因果关系：一项双向双样本孟德尔随机研究。

背景：年龄相关性黄斑变性（AMD）是老年人视力损害的主要原因。越来越多的证据表明代谢物与AMD之间可能存在关联。本研究旨在通过双向双样本孟德尔随机化方法评估血浆代谢物对AMD及其两种亚型的影响。方法：利用全基因组关联研究（GWAS）对1400种遗传决定代谢物（gdm）和AMD的汇总统计数据，通过双向双样本孟德尔随机化（MR）分析评估血浆代谢物与AMD之间的因果关系。本MR分析以方差反加权（IVW）为主要方法，加权中位数、MR- egger、加权模型和简单模型作为辅助方法来检验因果关系。采用MR-Egger截距、Cochran’s Q和MR-PRESSO检验来评估可能的多效性和异质性。结果：IVW结果显示13例gdm与AMD有显著的因果关系。1-硬脂酰gpe（18:0）、雄烯二醇（3β,17β）单硫酸盐、硬脂酰鞘磷脂（d18:1/18:0）、木糖和X-11,850对AMD有保护作用，而谷gulate和甘露酸盐增加AMD的风险。1-硬脂酰gpe（18:0）和X-11,850对干性AMD有保护作用。DHEAS、1-硬脂酰gpe（18:0）、5α-雄烯二醇-3β、17β-二醇二硫酸盐、木糖、雄烯二醇（3β,17β）单硫酸盐和n2 -乙酰基、N6、N6-二甲基lysine对湿性AMD有保护作用，而琥珀酰亚胺、16a-羟基DHEA -3 -硫酸盐和x - 13553增加湿性AMD的风险。水平多效性和异质性没有扭曲因果估计。在反向MR分析中，AMD降低雄烯二醇（3β,17β）单硫酸盐水平，升高硬脂酰鞘磷脂（d18:1/18:0）水平。结论：本研究支持血浆代谢物对AMD的影响，为临床诊断和预防策略提供了新的见解。

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来源期刊

Hereditas Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.80

自引率

3.70%

发文量

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.