White blood cell-to-haemoglobin ratio as a predictor of 30-day mortality in ICU patients with pulmonary hypertension: a MIMIC-IV database study.

IF 2 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

BMC Cardiovascular Disorders Pub Date : 2024-12-20 DOI:10.1186/s12872-024-04396-8

Shuangping Li, Shenshen Huang, Yuxuan Feng, Yimin Mao

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引用次数: 0

Abstract

Background and objective: The white blood cell-to-haemoglobin ratio (WHR) is a comprehensive indicator of inflammation and anaemia status. However, the relationship between the WHR and the risk of 30-day mortality among intensive care unit (ICU) patients with pulmonary hypertension (PH) remains unclear. The purpose of this study was to investigate the association between the WHR and 30-day mortality in critically ill patients with PH.

Methods: Clinical data of patients with PH were extracted from the MIMIC-IV (2.2) database. Restricted cubic splines and logistic regression analysis were used to investigate the relationship between the WHR and 30-day mortality. Subgroup analysis was used to assess the robustness of the results.

Results: A total of 451 patients with PH were enrolled, with 78 (17.3%) dying within 30 days. Restricted cubic spline analysis revealed a linear relationship between the WHR and 30-day mortality. Logistic regression analysis revealed the WHR was an independent predictor for 30-day mortality in critically ill patients with PH (OR, 1.58; 95% CI, 1.05-2.37; P = 0.028). The AUC of the WHR was 0.646 (95% CI: 0.60-0.69).

Conclusions: A higher WHR was an independent predictor for 30-day mortality in critically ill patients with PH.

Clinical trial number: Not applicable.

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白细胞与血红蛋白比率作为ICU肺动脉高压患者30天死亡率的预测因子：一项MIMIC-IV数据库研究

背景和目的：白细胞与血红蛋白比率（WHR）是炎症和贫血状态的综合指标。然而，重症监护病房（ICU）肺动脉高压（PH）患者的WHR与30天死亡风险之间的关系尚不清楚。本研究的目的是探讨PH危重患者WHR与30天死亡率之间的关系。方法：从MIMIC-IV（2.2）数据库中提取PH患者的临床资料。采用限制三次样条和logistic回归分析探讨WHR与30天死亡率之间的关系。采用亚组分析来评估结果的稳健性。结果：共纳入451例PH患者，其中78例（17.3%）在30天内死亡。限制三次样条分析揭示了WHR与30天死亡率之间的线性关系。Logistic回归分析显示，WHR是PH危重患者30天死亡率的独立预测因子(OR, 1.58；95% ci, 1.05-2.37；p = 0.028)。WHR的AUC为0.646 （95% CI: 0.60-0.69）。结论：较高的WHR是ph危重患者30天死亡率的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Cardiovascular Disorders CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.50

自引率

0.00%

发文量

480

审稿时长

1 months

期刊介绍： BMC Cardiovascular Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the heart and circulatory system, as well as related molecular and cell biology, genetics, pathophysiology, epidemiology, and controlled trials.