Anderson M Santos, Taynara O Silva, Maria H A Feitosa, Igor G S Oliveira, Ademar Wong, Robson S Souto, Fernando C Moraes, Luís A M Ruotolo, Willyam R P Barros, Marcos R V Lanza
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引用次数: 0
Abstract
This study reports the development and implementation of a straightforward, rapid, and cost-effective voltammetric technique for piroxicam (PIR) detection at nanomolar concentrations in biological and environmental samples. The method involved the use of a screen-printed electrode (SPE) enhanced with a combination of Printex L6 carbon (PL6C) and polyaniline-based activated carbon (PAC) on a chitosan film crosslinked with epichlorohydrin (CTS:EPH). The detection was carried out using square-wave adsorptive anodic stripping voltammetry (SWAdASV) in a 0.10 mol L-1 phosphate buffer solution at pH 6.0. The approach employed yielded a low limit of detection of 4.5 × 10-9 mol L-1 and a linear range of 5.0 × 10-8 to 8.8 × 10-6 mol L-1 (r = 0.999). The PAC-PL6C-CTS:EPH/SPE sensor was effectively employed for PIR detection in synthetic urine and river water samples, where its reliability was proven through addition and recovery tests. The results obtained from the application of the proposed voltammetric method closely matched those recorded under high-performance liquid chromatography (HPLC), which was used as a reference method. The findings show that the technique proposed in this study offers a simple, quick, and highly effective alternative mechanism for PIR detection in both biological and environmental matrices.
期刊介绍：
Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome.
Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.
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