Gold nanoclusters decorated hollow ZIF-8 encapsulating iron-catecholates as oxidase mimetics for ratiometric colorimetric detection of nitrite

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2024-12-21 DOI:10.1007/s00604-024-06879-z

Cunhui Wu, Mengzhen Dai, Xinguang Qin, Gang Liu, Haizhi Zhang

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Abstract

Gold nanoclusters decorated hollow ZIF-8 encapsulating iron-catecholates (Fe-HHTP@HZIF-8@ AuNCs) was formed through self-assembly of Fe³⁺ and 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP), in situ embedding of ZIF-8, and Au³⁺-Zn²⁺ exchange reaction. Its morphology and structure were fully characterized by high-resolution transmission electron microscopy, X-ray diffraction, transmission electron microscopy element mapping, and X-ray photoelectron spectroscopy. Additionally, its oxidase-like activity was explored with K_m of 0.21 mM and V_max of 1.74 × 10⁻⁶ M·s⁻¹ toward 3,3′,5,5′-tetramethylbenzidine (TMB). Due to its excellent catalytic activity and nitrite mediated diazotization of oxTMB, a ratiometric colorimetric method for nitrite detection was established and validated with wide linear range (2.0–400.0 μM), low LOD (0.12 μM), high accuracy (recovery of 95.11–102.14%), and good selectivity. This method was then utilized to determine the nitrite content in sausages and tap water. This study provided a new idea for developing efficient nanozymes and offered an accurate approach for nitrite determination.

Graphical Abstract

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金纳米团簇装饰空心ZIF-8包封铁儿茶酚酸盐作为氧化酶模拟物用于比例比色法检测亚硝酸盐

通过Fe3+与2,3,6,7,10,11-六羟基三苯（HHTP）的自组装、ZIF-8的原位包埋和Au3+-Zn2+交换反应，形成了装饰金纳米团簇的空心ZIF-8包封铁-茶酸盐（Fe-HHTP@HZIF-8@ AuNCs）。通过高分辨率透射电子显微镜、x射线衍射、透射电子显微镜元素作图、x射线光电子能谱等手段对其形貌和结构进行了全面表征。此外，在Km为0.21 mM， Vmax为1.74 × 10−6 M·s−1的条件下，对3,3 ',5,5 ' -四甲基联苯胺（TMB）具有类似氧化酶的活性。由于其优异的催化活性和亚硝酸盐介导的氧化tmb重氮化作用，建立了亚硝酸盐的比例比色检测方法，线性范围宽（2.0 ~ 400.0 μM）， LOD低（0.12 μM），准确度高（回收率95.11 ~ 102.14%），选择性好。并将该方法应用于香肠和自来水中亚硝酸盐含量的测定。该研究为开发高效纳米酶提供了新思路，并为亚硝酸盐的准确测定提供了新方法。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.