Preparation of magnetic covalent organic framework nanoparticles with multi-active site at room temperature for enrichment of Paclitaxel from Taxus cuspidata

IF 6.3 2区材料科学 Q2 CHEMISTRY, PHYSICAL

Applied Surface Science Pub Date : 2024-12-22 DOI:10.1016/j.apsusc.2024.162185

Wenlong Li, Sun Yu, Yuanhu Tang, Yunze Ren, Shujie Wang

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Abstract

Paclitaxel (PTX) is an anticancer compound with significant economic value found in Taxus cuspidata. Given the complex composition of the T. cuspidata substrates and the low content of PTX, developing an efficient and rapid extraction method is crucial. In this study, a magnetic covalent organic framework (MCOF-TTA-PDA) was synthesized at room temperature for the rapid extraction of PTX from T. cuspidata. The results showed that MCOF-TTA-PDA demonstrated large specific surface areas, high pore volume, superparamagnetic properties, desirable recyclability, and significant adsorption capacity for PTX. Additionally, the adsorption property experiment showed that the adsorption behavior of MCOF-TTA-PDA was more consistent with the Langmuir and the pseudo-second-order kinetic model. Furthermore, the strongly electronegative pyridine and triazine functional groups on MCOF-TTA-PDA’s surface enhanced its adsorption capacity. The adsorption mechanism was further explored using molecular simulations (DFT) and XPS. The results indicated that the excellent properties were mainly attributed to π-π stacking, multiple hydrogen bonding sites provided by pyridine/triazine, and suitable pore size. The MCOF was successfully used for the extraction of PTX from T. cuspidata and the enrichment ratio was 3.06 times. These results demonstrated that MCOF-TTA-PDA has the potential for efficient extraction of PTX from T. cuspidata.

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紫杉醇（PTX）是一种抗癌化合物，在紫杉（Taxus cuspidata）中发现，具有重要的经济价值。鉴于紫杉底物成分复杂且 PTX 含量较低，开发一种高效快速的提取方法至关重要。本研究在室温下合成了一种磁性共价有机框架（MCOF-TTA-PDA），用于从 T. cuspidata 中快速提取 PTX。结果表明，MCOF-TTA-PDA 具有大比表面积、高孔隙率、超顺磁性、理想的可回收性以及对 PTX 的显著吸附能力。此外，吸附特性实验表明，MCOF-TTA-PDA 的吸附行为更符合 Langmuir 和伪秒阶动力学模型。此外，MCOF-TTA-PDA 表面的强电负性吡啶和三嗪官能团增强了其吸附能力。利用分子模拟（DFT）和 XPS 进一步探讨了吸附机理。结果表明，其优异的性能主要归功于π-π堆叠、吡啶/三嗪提供的多个氢键位点以及合适的孔径。MCOF 成功用于从 T. cuspidata 中提取 PTX，富集比为 3.06 倍。这些结果表明，MCOF-TTA-PDA 具有从 Tuspidata 中高效提取 PTX 的潜力。

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来源期刊

Applied Surface Science 工程技术-材料科学：膜

CiteScore

12.50

自引率

7.50%

发文量

3393

审稿时长

67 days

期刊介绍： Applied Surface Science covers topics contributing to a better understanding of surfaces, interfaces, nanostructures and their applications. The journal is concerned with scientific research on the atomic and molecular level of material properties determined with specific surface analytical techniques and/or computational methods, as well as the processing of such structures.