Efficacy of secukinumab in Takayasu arteritis with myocardial infarction complicated with generalized pustular psoriasis: A case report.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medicine Pub Date : 2024-12-20 DOI:10.1097/MD.0000000000040994

Tomoyuki Asano, Shuhei Yoshida, Naoki Matsuoka, Masato Ishikawa, Akihiko Sato, Shotaro Ogawa, Kenji Saito, Yuya Sumichika, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Shuzo Sato, Yasuchika Takeishi, Toshiyuki Yamamoto, Kiyoshi Migita

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引用次数: 0

Abstract

Rationale: Takayasu arteritis (TAK) is an autoimmune disease that causes chronic inflammation targeting the aortic wall. Since many patients are resistant to steroid treatment, multiple immunosuppressants or interleukin-6 (IL-6) suppression therapy have served as treatment alternatives. However, there are very few reports on the effectiveness of biologics against inflammatory cytokines upstream of IL-6.

Patient concerns: We present a case of TAK in a 51-year-old female presenting with a myocardial infarction. She had persistent carotid wall thickening despite glucocorticoid (GC) therapy, and IL-6 suppression therapy was being proactively considered. While the GC was being tapered, widespread pustules appeared all over her body.

Diagnosis: TAK complicated with generalized pustular psoriasis (GPP).

Interventions: Aside from GC, the patient was treated with secukinumab (SEC), an anti-IL-17A monoclonal antibody.

Outcomes: Immediately after treatment with SEC, the pustules disappeared, and the thickening of the common carotid artery wall improved on ultrasound.

Lessons: Since IL-17 is an important cytokine in the pathogenesis of TAK, anti-cytokine therapy targeting IL-17 may be effective for TAK.

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

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