The accuracy and efficiency of the wheel-rail adhesion model are important to the wheel-rail rolling contact issues. The purpose of this study is to develop a simplified non-Hertzian wheel-rail adhesion model under interfacial contaminations to predict the wheel-rail adhesion coefficient. Firstly, a non-Hertzian full elasto-hydrodynamic lubrication (EHL) model was developed and applied to determine the wheel-rail contact pressure and film thickness under interfacial contaminations. Then, the empirical formula of central film thickness available to non-Hertzian wheel-rail normal contact relating to train speeds, axle loads and material parameters were proposed based on a large number of non-Hertzian full EHL simulation for smooth surface under interfacial contaminations using linear regression. The empirical non-Hertzian central film thickness formula and minimum film thickness formula for wheel-rail contact obtained in this paper show certain differences from the formulas based on Hertzian contact. Using the proposed non-Hertzian central film thickness formula, a simplified non-Hertzian wheel-rail contact adhesion model was developed, and the adhesion coefficient was obtained at different speeds and compared with the field test data. The numerical results showed good agreement with field test data.