Trait responsiveness to verbal suggestions predicts nocebo responding: A meta-analysis

IF 3.5 2区心理学 Q1 PSYCHOLOGY, CLINICAL

British Journal of Health Psychology Pub Date : 2024-12-20 DOI:10.1111/bjhp.12774

Madeline V. Stein, Monika Heller, Sarah Chapman, G. James Rubin, Devin B. Terhune

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Abstract

Background

Nocebo responding involves the experience of adverse health outcomes in response to contextual cues. These deleterious responses impact numerous features of mental and physical health but are characterized by pronounced heterogeneity. Suggestion is widely recognized as a contributing factor to nocebo responding but the moderating role of trait responsiveness to verbal suggestions (suggestibility) in nocebo responding remains poorly understood.

Objective

We conducted a pre-registered meta-analysis (PROSPERO registration number CRD42023425605) to quantitatively synthesize available research on the relationship between suggestibility and nocebo responding.

Methods

Four electronic databases were searched for original studies involving both the assessment of suggestibility and symptom reports in response to an inactive stimulus.

Results

Of 7729 search results, 10 articles presenting 13 correlations between suggestibility and nocebo responding were analysed. A random-effects meta-analysis revealed a significant, albeit weak, positive correlation, r = .21 [95% CI: .04, .37], between suggestibility and nocebo responses, such that more highly suggestible individuals displayed larger responses. Sensitivity and meta-regression analyses demonstrated that studies of higher methodological quality, including those that maintained experimenter blinding, exhibited stronger effect sizes.

Conclusion

These results corroborate proposals that trait responsiveness to verbal suggestions confers greater response to nocebos and warrants renewed attention to the role of suggestibility in symptom induction and perception.

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对言语暗示的特质反应预测反安慰剂反应：一项元分析

研究背景：反安慰剂反应涉及到情境线索对不良健康结果的反应。这些有害的反应影响心理和身体健康的许多特征，但具有明显的异质性。建议被广泛认为是反安慰剂反应的一个促进因素，但对言语建议的特质反应性（易受暗示）在反安慰剂反应中的调节作用仍然知之甚少。目的我们进行了一项预注册荟萃分析（PROSPERO注册号CRD42023425605），以定量综合现有的关于易受暗示与反安慰剂反应之间关系的研究。方法检索4个电子数据库中有关非活动刺激的易受暗示性评估和症状报告的原始研究。结果在7729个搜索结果中，分析了10篇文章，其中包含13个暗示与反安慰剂反应之间的相关性。随机效应荟萃分析显示，尽管弱，但显著正相关，r =。21 [95% CI: .04, .37]，在易受暗示和反安慰剂反应之间，高易受暗示的个体表现出更大的反应。敏感性和元回归分析表明，方法学质量较高的研究，包括那些保持实验者盲法的研究，显示出更强的效应值。结论这些结果证实了对言语暗示的特质反应性对反安慰剂的反应更大，并值得重新关注暗示在症状诱导和感知中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Health Psychology PSYCHOLOGY, CLINICAL-

CiteScore

14.10

自引率

1.30%

发文量

期刊介绍： The focus of the British Journal of Health Psychology is to publish original research on various aspects of psychology that are related to health, health-related behavior, and illness throughout a person's life. The journal specifically seeks articles that are based on health psychology theory or discuss theoretical matters within the field.