Nanotechnology-Based Systems for Enhancing the Efficacy of Sonodynamic Therapy in Cancer Treatment

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Yidong Wang, Nikolitsa Nomikou
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Abstract

Sonodynamic therapy (SDT) is a minimally invasive cancer therapeutic modality that utilizes low-intensity ultrasound to activate sensitizers for the production of cytotoxic reactive oxygen species (ROS) and the site-specific ablation of tumors. Compared to conventional cancer treatments, SDT has no adverse side effects, has been shown to radically reduce tumor volume, and has the potential to raise antitumor immune response. Ever-increasing studies have demonstrated that nanotechnology can significantly enhance the efficacy of SDT against certain cancers and improve its therapeutic effects. Nanosystems are developed that can improve the intratumoral delivery and cellular uptake of sensitizers, can reduce intrinsic cancer defenses against ROS, can act synergistically for the production of ROS and can tackle cancer immune tolerance. In this review, the various strategies to enhance SDT performance with the assistance of nanotechnology, and the outstanding research outcomes, are discussed.

Abstract Image

基于纳米技术的系统提高声动力治疗在癌症治疗中的疗效
声动力治疗(SDT)是一种微创癌症治疗方式,利用低强度超声激活致敏剂,产生细胞毒性活性氧(ROS),并对肿瘤进行部位特异性消融。与传统的癌症治疗相比,SDT没有不良副作用,已被证明可以从根本上减少肿瘤体积,并有可能提高抗肿瘤免疫反应。越来越多的研究表明,纳米技术可以显著提高SDT对某些癌症的疗效,并改善其治疗效果。纳米系统可以改善肿瘤内致敏剂的传递和细胞摄取,可以降低对ROS的内在癌症防御,可以协同作用于ROS的产生,并可以解决癌症免疫耐受。本文综述了利用纳米技术提高SDT性能的各种策略和突出的研究成果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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