A Near-Infrared-II Fluorescent Nanoprobe Offering Real-Time Tracking of Fenton-Like Reaction for Cancer Chemodynamic Theranostics

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2024-12-20 DOI:10.1021/acs.nanolett.4c05087

Jingwen Sun, Shuai Gao, Guoguang Wei, Sheng Yu, Sihang Zhang, Afeng Yang, Wei Lu

{"title":"A Near-Infrared-II Fluorescent Nanoprobe Offering Real-Time Tracking of Fenton-Like Reaction for Cancer Chemodynamic Theranostics","authors":"Jingwen Sun, Shuai Gao, Guoguang Wei, Sheng Yu, Sihang Zhang, Afeng Yang, Wei Lu","doi":"10.1021/acs.nanolett.4c05087","DOIUrl":null,"url":null,"abstract":"Chemodynamic therapy (CDT) utilizing Fenton or Fenton-like reactions to generate cytotoxic hydroxyl radicals by metal ions has become a compelling strategy for cancer treatment. Visualizing intratumoral Fenton or Fenton-like reactions especially at a cellular level in real-time can directly monitor the process of CDT, which is not yet feasible. Here, we present a molecule BADA chelating Cu2+ to form Cu-BADA nanoparticles, exhibiting fluorescence quenching properties through intermolecular electron transfer. The nanoparticles are lit up owing to glutathione and acid dual activatable Fenton-like reaction and generation of near-infrared-II fluorescent o-quinones. Moreover, fluorescence vanishing correlated with the decreased intratumoral Cu concentration, thus enabling to track the “on–off” process of Fenton-like reaction specifically in the tumor. Compared to 660 nm-excitation, the o-quinones excited at 830 nm offer deeper tissue near-infrared-II fluorescence imaging with higher resolution. Our results demonstrate a fluorescence nanotheranostic agent for CDT capable of monitoring the spatiotemporal dynamics of Fenton-like reaction.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"29 1","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Letters","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acs.nanolett.4c05087","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Chemodynamic therapy (CDT) utilizing Fenton or Fenton-like reactions to generate cytotoxic hydroxyl radicals by metal ions has become a compelling strategy for cancer treatment. Visualizing intratumoral Fenton or Fenton-like reactions especially at a cellular level in real-time can directly monitor the process of CDT, which is not yet feasible. Here, we present a molecule BADA chelating Cu²⁺ to form Cu-BADA nanoparticles, exhibiting fluorescence quenching properties through intermolecular electron transfer. The nanoparticles are lit up owing to glutathione and acid dual activatable Fenton-like reaction and generation of near-infrared-II fluorescent o-quinones. Moreover, fluorescence vanishing correlated with the decreased intratumoral Cu concentration, thus enabling to track the “on–off” process of Fenton-like reaction specifically in the tumor. Compared to 660 nm-excitation, the o-quinones excited at 830 nm offer deeper tissue near-infrared-II fluorescence imaging with higher resolution. Our results demonstrate a fluorescence nanotheranostic agent for CDT capable of monitoring the spatiotemporal dynamics of Fenton-like reaction.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.