Ultrasensitive infrared spectroscopy via vibrational modulation of plasmonic scattering from a nanocavity

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2024-12-20 DOI:10.1126/sciadv.adn8255

Danchen Jia, Ran Cheng, James H. McNeely, Haonan Zong, Xinyan Teng, Xinxin Xu, Ji-Xin Cheng

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Abstract

Most molecules and dielectric materials have characteristic bond vibrations or phonon modes in the mid-infrared regime. However, infrared absorption spectroscopy lacks the sensitivity for detecting trace analytes due to the low quantum efficiency of infrared sensors. Here, we report mid-infrared photothermal plasmonic scattering (MIP-PS) spectroscopy to push the infrared detection limit toward nearly a hundred molecules in a plasmonic nanocavity. The plasmon scattering from a nanoparticle-on-film cavity has extremely high sensitivity to the spacing defined by the analyte molecules inside the nanogap. Meanwhile, a 1000-fold infrared light intensity enhancement at the bond vibration frequency further boosts the interaction between mid-IR photons and analyte molecules. MIP-PS spectroscopic detection of nitrile or nitro group in ~130 molecules was demonstrated. This method heralds potential in ultrasensitive bond-selective biosensing and bioimaging.

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超灵敏红外光谱通过振动调制等离子体散射从纳米腔

大多数分子和介电材料在中红外波段具有典型的键振动或声子模式。然而，由于红外传感器的量子效率较低，红外吸收光谱检测痕量分析物缺乏灵敏度。在这里，我们报道了中红外光热等离子体散射（MIP-PS）光谱将红外探测极限推向等离子体纳米腔中近100个分子。薄膜上纳米粒子腔的等离子体散射对纳米间隙内分析物分子所定义的间距具有极高的灵敏度。同时，在键振动频率处1000倍的红外光强度增强进一步增强了中红外光子与分析物分子之间的相互作用。用MIP-PS光谱检测了约130个分子中的腈或硝基。该方法预示着超灵敏键选择生物传感和生物成像的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.