{"title":"Timing of rejection events preceded by Covid-19 mRNA vaccination in recipients of solid organ transplants.","authors":"Quentin Perrier, Johan Noble, Agnès Bonadona, Caroline Augier, Thomas Jouve, Aude Boignard, Loïc Falque, Salomé Gallet, Pierrick Bedouch, Lionel Rostaing, Olivier Epaulard","doi":"10.1016/j.vaccine.2024.126617","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>SARS-CoV-2 mRNA vaccine reactogenicity has raised concerns regarding the risk of rejection in solid organ transplant recipients. We explored whether SOT recipients diagnosed with acute rejection had previously received a vaccine injection within a timeframe consistent with a causal link.</p><p><strong>Methods: </strong>We identified all SOT recipients with a diagnosis of acute rejection from 2020 to 2022 and who had previously received a SARS-CoV-2 vaccination, and analysed whether the delay between vaccination and rejection was constant.</p><p><strong>Results: </strong>In the 45 identified patients, median delay between the last SARS-CoV-2 vaccination and the rejection was 102 days [IQR 48-178]; the continuous distribution of this delay, with no identifiable time pattern, is not in favor of a role of vaccination in rejection.</p><p><strong>Conclusion: </strong>SARS-CoV-2 mRNA vaccination is unlikely to trigger rejection in SOT recipients.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"45 ","pages":"126617"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vaccine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.vaccine.2024.126617","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: SARS-CoV-2 mRNA vaccine reactogenicity has raised concerns regarding the risk of rejection in solid organ transplant recipients. We explored whether SOT recipients diagnosed with acute rejection had previously received a vaccine injection within a timeframe consistent with a causal link.
Methods: We identified all SOT recipients with a diagnosis of acute rejection from 2020 to 2022 and who had previously received a SARS-CoV-2 vaccination, and analysed whether the delay between vaccination and rejection was constant.
Results: In the 45 identified patients, median delay between the last SARS-CoV-2 vaccination and the rejection was 102 days [IQR 48-178]; the continuous distribution of this delay, with no identifiable time pattern, is not in favor of a role of vaccination in rejection.
Conclusion: SARS-CoV-2 mRNA vaccination is unlikely to trigger rejection in SOT recipients.
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