Prevalence and risk factors of frailty in older patients with coronary heart disease: A systematic review and meta-analysis

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-12-15 DOI:10.1016/j.archger.2024.105721

Tao Li , Wenting Shi , Guorong Wang , Yunlan Jiang

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引用次数: 0

Abstract

Objective

To quantitatively synthesise evidence on the prevalence of and risk factors of frailty in older patients with coronary heart disease.

Methods

Nine electronic databases were searched from the inception to July 20th 2024. Random-effects model was performed to calculate to estimate the prevalence of frailty in older patients with coronary heart disease. Meta-regression analysis and subgroup analysis were conducted to explore the potential sources of heterogeneity. Sensitivity analysis was conducted using a study-by-study exclusion method. Meta-analysis of risk factors was performed using the Mantel-Haenszel or inverse variance method and only on the risk factors that have been reported in a minimum of two studies.

Results

A total of 42 studies from 5 countries met the inclusion criteria, involving 11954 older patients. The pooled prevalence in older adults with coronary heart disease was 36% (95%CI: 31%-40%) for frailty. We found a higher prevalence of frailty among older patients with coronary heart disease in females, ≥80 years, case-control studies, EFS evaluation tool and acute coronary syndrome. Age, female, cardiac classification, malnutrition, fall within 1 year, sleep disorder, hypoproteinemia (albumin<35g/L), low level of literacy, depression, anxiety, low BMI, polypharmacy, comorbidities, CCI, diabetes, hypertension, high level of BNP, ADL disability, gait speed, living alone, low level of 25(OH)D₃ were risk factors of frailty among older patients with coronary heart disease.

Conclusions

Coronary heart disease patients have a significantly higher prevalence of frailty. Early screening and timely prevention of frailty by medical practitioners are needed to provide more targeted measures for CHD patients.

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老年冠心病患者虚弱的患病率和危险因素：系统回顾和荟萃分析

目的：定量综合老年冠心病患者虚弱的患病率及危险因素的证据。方法：检索自建库至2024年7月20日的9个电子数据库。采用随机效应模型计算和估计老年冠心病患者的虚弱患病率。采用meta回归分析和亚组分析探讨异质性的潜在来源。采用逐项研究排除法进行敏感性分析。使用Mantel-Haenszel或反方差法对危险因素进行荟萃分析，仅对至少两项研究中报告的危险因素进行荟萃分析。结果：来自5个国家的42项研究符合纳入标准，涉及11954例老年患者。老年冠心病患者虚弱的总患病率为36% （95%CI: 31%-40%）。我们发现，年龄≥80岁的老年女性冠心病患者、病例对照研究、EFS评估工具和急性冠状动脉综合征中虚弱的患病率较高。年龄、女性、心脏类型、营养不良、1年内跌倒、睡眠障碍、低蛋白血症（白蛋白3）是老年冠心病患者虚弱的危险因素。结论：冠心病患者虚弱患病率明显增高。需要医生早期筛查和及时预防虚弱，为冠心病患者提供更有针对性的措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.