Propargylic‐linked [5]helicene derivative for selective Au3+ detection in near‐perfect aqueous media with applications in diverse real samples, paper test strips, and human cells

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2024-12-14 DOI:10.1016/j.saa.2024.125594

Nirawit Kaewnok , Nirumon Chailek , Sopida Thavornpradit , Sirilak Wangngae , Anuwut Petdum , Waraporn Panchan , Anyanee Kamkaew , Jitnapa Sirirak , Thanasat Sooksimuang , Natdhera Sanmanee , Phornphimon Maitarad , Nantanit Wanichacheva

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Abstract

Gold is classified as a heavy metal, and its ion (Au³⁺) can manifest adverse impacts on ecological and human health. Thus, an effective method for Au³⁺ detection is highly required. In this work, a new [5]helicene‐based fluorescence sensor (M202P) was synthesized and applied for Au³⁺ monitoring in near-perfect aqueous media. M202P rapidly detected Au³⁺ through a fluorescence quenching response and furnished a large Stokes shift of 157 nm. The Au³⁺ sensing ability of M202P allowed it to withstand interference from other metal ions, with a detection limit for Au³⁺ of 8.0 ppb. The mechanism underlying its Au³⁺ detection was the coordination of Au³⁺ with the alkyne and carbonyl oxygen, leading to the later hydration of alkynyl moiety, as thoroughly proven by FTIR, ¹H NMR, ¹³C NMR, and HRMS, with the stoichiometric ratio of 1:1 according to Job’s plot. In addition, M202P can be used for the quantitative analysis and qualitative fluorescence assay of Au³⁺ levels in environmental waters and fertilizer solutions. This sensor also demonstrated high potential as a fluorescence tracking agent in human cells and was utilized in fabricating a paper test strip.

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丙炔连接[5]螺旋烯衍生物，用于在接近完美的水介质中选择性检测Au3+，应用于各种实际样品，试纸条和人类细胞。

金属于重金属，其离子（Au3+）会对生态和人类健康产生不利影响。因此，亟需一种有效的 Au3+ 检测方法。本研究合成了一种新的基于[5]螺旋烯的荧光传感器（M202P），并将其应用于近乎完美的水介质中的 Au3+ 监测。M202P 可通过荧光淬灭反应快速检测 Au3+，并产生 157 nm 的大斯托克斯位移。M202P 的 Au3+ 检测能力使其能够抵御其他金属离子的干扰，Au3+ 的检测限为 8.0 ppb。傅立叶变换红外光谱、1H NMR、13C NMR 和 HRMS 都充分证明了其 Au3+ 检测机制是 Au3+ 与炔基和羰基氧配位，随后导致炔基水合，根据约伯图，其化学计量比为 1:1。此外，M202P 还可用于环境水和肥料溶液中 Au3+ 含量的定量分析和定性荧光检测。该传感器还显示出作为人体细胞荧光跟踪剂的巨大潜力，并被用于制造纸质试纸。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.