Bacterial ghosts: A breakthrough approach to cancer vaccination

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedicine & Pharmacotherapy Pub Date : 2025-01-01 DOI:10.1016/j.biopha.2024.117766

Muneera Anwer, Krupa Bhaliya, Alan Munn, Ming Q. Wei

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Abstract

Cancer is a devastating disease worldwide with high mortality rates and is a foremost concern for society. Immunotherapy has emerged as a promising strategy for treating cancer, harnessing the power of immune system to recognize and kill tumor cells. Bacterial ghosts (BGs), a novel platform in cancer vaccination, are suitable for personalized and effective immunotherapeutic interventions. BG are empty bacterial cell envelopes generated through a controlled lysis process, leaving behind empty but structurally intact cell membranes. BGs have been used as vaccine adjuvants and vaccine delivery vehicles worldwide. They possess inherent immunogenicity, enabling them to be used for controlled release and targeted drug delivery. Recently, the potential of BGs has been explored for tumor inhibition, making them suitable carrier vehicles. This review highlights cancer immunotherapy, methods of BG preparation, characterization of BGs, the interaction of BGs with the immune system, and research progress on BG-based cancer vaccines with future insights.

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细菌幽灵：癌症疫苗接种的突破性方法。

癌症是世界范围内的一种高死亡率的毁灭性疾病，是社会最关心的问题。免疫疗法已经成为一种很有前途的治疗癌症的策略，利用免疫系统的力量来识别和杀死肿瘤细胞。细菌幽灵（BGs）是一种新的癌症疫苗接种平台，适合于个性化和有效的免疫治疗干预。BG是通过控制裂解过程产生的空的细菌细胞包膜，留下空的但结构完整的细胞膜。BGs在世界范围内被用作疫苗佐剂和疫苗递送载体。它们具有固有的免疫原性，使它们能够用于控释和靶向给药。近年来，人们对BGs的肿瘤抑制潜力进行了探索，使其成为合适的载体。本文综述了肿瘤免疫治疗、BG制备方法、BG的表征、BG与免疫系统的相互作用，以及基于BG的肿瘤疫苗的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.