Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy.

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-20 DOI:10.1080/17435889.2024.2440301
Khusbu Dwivedi, Ankit Sahoo, Waleed H Almalki, Salem Salman Almujri, Alhussain Aodah, Nabil K Alruwaili, Safia Obaidur Rab, Abdulkareem Ali Alanezi, Esraa M Haji, Md Abul Barkat, Tanuja Singh, Mahfoozur Rahman
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Abstract

Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations such as high metabolism, poor absorption, and high dosage requirements. Challenges in the large-scale isolation of phytoactive compounds, solubility, bioavailability, and targeting limit their development. Recent developments, including carbohydrate, lipid, and protein-based nanoparticles, have enhanced cancer treatment by improving the bioavailability and targeted delivery of phytoactives such as polyphenols, alkaloids, sulfur-containing compounds, flavonoids, and terpenes. Despite advancements, clinical application faces hurdles such as poor bioavailability and inconsistent immune responses. This article discusses the promise of phytoactive-loaded nanoformulations in cancer management, highlighting targeted drug delivery, unmet needs, and challenges. Further research is needed to overcome these challenges and fully understand the potential of phytoactives in cancer management.

创新的纳米载体系统,用于增强癌症治疗中植物活性化合物的递送。
全世界有数百万人患有癌症,面临着诸如影响健康细胞的治疗、次优反应、不良反应、复发风险、耐药性和非特异性靶向等挑战。化疗耐药导致死亡,但植物活性物质在癌症治疗中显示出希望,尽管存在高代谢、吸收不良和高剂量要求等局限性。植物活性化合物的大规模分离、溶解度、生物利用度和靶向性等方面的挑战限制了它们的发展。最近的发展,包括基于碳水化合物、脂质和蛋白质的纳米颗粒,通过提高植物活性物质(如多酚、生物碱、含硫化合物、类黄酮和萜烯)的生物利用度和靶向递送,加强了癌症治疗。尽管取得了进展,但临床应用面临诸如生物利用度差和免疫反应不一致等障碍。本文讨论了植物活性负载纳米制剂在癌症管理中的前景,强调了靶向药物递送,未满足的需求和挑战。需要进一步的研究来克服这些挑战,并充分了解植物活性物质在癌症管理中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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