Diagnostic accuracy of neonatal structural MRI scores to predict 6-year motor outcomes of children born very preterm

IF 3.4 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2025-01-01 DOI:10.1016/j.nicl.2024.103725

Karen H. Mistry , Samudragupta Bora , Kerstin Pannek , Alex M. Pagnozzi , Simona Fiori , Andrea Guzzetta , Robert S. Ware , Paul B. Colditz , Roslyn N. Boyd , Joanne M. George

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引用次数: 0

Abstract

Aims

This study aimed to (1) evaluate associations between Early and Term structural MRI (sMRI) brain abnormality scores and adverse motor outcomes at 6-years corrected age (CA), (2) determine their diagnostic accuracy in predicting adverse motor outcomes and cerebral palsy (CP) at 6-years CA.

Methods

Infants born < 31-weeks gestational age (GA) returning for 6-year follow-up were included. Early and Term sMRI were scored using a validated method, deriving white matter, cortical grey matter, deep grey matter, cerebellar and global brain abnormality scores (GBAS). At 6-years CA, Movement Assessment Battery for Children-2nd Edition (MABC-2) was administered. Linear regression assessed associations between Early and Term GBAS/subscale scores and 6-year MABC-2 total score. For diagnostic accuracy, sMRI scores were categorised as none/mild vs moderate/severe, MABC-2 cut-off ≤ 5th percentile, and CP as present/absent.

Results

Infants had Early MRI (n = 123) at mean PMA 32.5-weeks (median GA 28.4-weeks; mean birthweight 1101 g) and n = 114 had Term MRI (Mean PMA 40.8-weeks). Nine had CP and n = 116 had MABC-2 scores. Early (B: −1.92; p ≤ 0.001) and Term (B: −1.67; p ≤ 0.01) GBAS were negatively associated with MABC-2 scores. Both Early and Term GBAS had high specificity (Sp) and low sensitivity (Se) in predicting MABC-2 ≤ 5th percentile (Early: Se 36 %, Sp 82 %; Term: Se 28 %, Sp 93 %) and predicted CP with high Se and Sp (Early: Se 78 %, Sp 78 %; Term: Se 75 %, Sp 89 %).

Conclusion

High Sp of Early and Term MRI predicting an outcome on MABC-2 may help accurately identify infants unlikely to develop motor impairments at 6-years CA.

查看原文本刊更多论文

新生儿结构MRI评分预测早产儿6年运动预后的诊断准确性。

目的：本研究旨在(1)评估早期和足月结构MRI （sMRI）脑异常评分与6岁矫正年龄（CA）不良运动结局之间的关系，(2)确定其预测6岁矫正年龄（CA）不良运动结局和脑瘫（CP）的诊断准确性。方法：婴儿出生结果：婴儿早期MRI （n = 123）平均PMA 32.5周(中位GA 28.4周；平均出生体重1101 g)和n = 114进行了中期MRI（平均PMA为40.8周）。9例有CP， 116例有MABC-2评分。早盘(B: -1.92；p≤0.001)和Term (B: -1.67；p≤0.01)GBAS与MABC-2评分呈负相关。早期和中期GBAS在预测MABC-2≤5百分位数方面具有高特异性（Sp）和低敏感性（Se）(早期：Se 36%， Sp 82%；期：Se 28%， Sp 93%)，高Se和Sp预测CP(早期：Se 78%， Sp 78%；期限：Se 75%， Sp 89%)。结论：早期和足月MRI的高Sp值预测MABC-2的结果可能有助于准确识别6岁时不太可能发生运动障碍的婴儿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.