Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals.

IF 3.8 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Chengwu Lu, Chao Song, Yunlong Yu, Linhai Yang, Wu Zheng, Fenqi Luo, Yuhua Xiao, Jun Luo, Jie Xu
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Abstract

Mechanical properties and integrity of biodegradable Zn alloys during degradation holds significant importance. In this study, a Zn-Mg-Mn alloy with tensile strength of 414 MPa and an elongation of 26% was developed. The strength contributions of as-extruded Zn alloy from grain boundary strengthening, precipitation strengthening, and second phase strengthening. Degradation of the Zn alloy in Hank's solution exhibited a decreasing trend with prolonged immersion, eventually stabilizing at 16 μm/year. Corrosion morphology analysis revealed that the corrosion modes transformed from pitting corrosion to severely localized corrosion with prolonged immersion time, eventually lead to formation of large holes. Although the tensile strength of the Zn alloys remained relatively unchanged following varied immersion time, a substantial decrease in elongation was observed. The decreased elongation primarily attributed to the formation of surface corrosion pits or holes, exacerbating crack propagation during tension. Biocompatibility assessments of Zn alloys demonstrated that a 50% concentration of Zn alloy leach solution cultured with C3H10 and RMSC cells yielded cellular activity exceeding 80%, indicating excellent cytocompatibility. Alkaline phosphatase (ALP) and alizarin red staining results further underscored the remarkable early and late osteogenic properties exhibited by Zn-Mg-Mn alloy.

具有高强度和适当机械完整性的可生物降解锌合金作为骨修复金属。
生物可降解锌合金在降解过程中的力学性能和完整性具有重要意义。本研究制备了一种抗拉强度为414 MPa、伸长率为26%的Zn-Mg-Mn合金。挤压态Zn合金的强度贡献来自晶界强化、析出强化和第二相强化。随着浸泡时间的延长,Zn合金在Hank’s溶液中的降解呈下降趋势,最终稳定在16 μm/年。腐蚀形貌分析表明,随着浸泡时间的延长,腐蚀模式由点蚀转变为严重局部腐蚀,最终形成大孔洞。虽然锌合金的抗拉强度在不同浸泡时间下保持相对不变,但伸长率明显下降。伸长率的下降主要是由于表面腐蚀坑或孔洞的形成,加剧了拉伸过程中裂纹的扩展。锌合金的生物相容性评估表明,50%浓度的锌合金浸出液与C3H10和RMSC细胞培养,细胞活性超过80%,表明具有良好的细胞相容性。碱性磷酸酶(ALP)和茜素红染色结果进一步强调了锌-镁-锰合金早期和晚期成骨的显著特性。
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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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