Ly6G⁺ Neutrophils and Interleukin-17 Are Essential in Protection against Rodent Malaria Caused by Plasmodium berghei ANKA.

IF 11 1区综合性期刊 Q1 Multidisciplinary

Research Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI:10.34133/research.0559

Ziwei Su, Qilong Li, Yiwei Zhang, Tong Liu, Kunying Lv, Anni Feng, Yixin Yang, Yanxin Zhang, Zhiming Wei, Xiaoyu Sang, Ying Feng, Ran Chen, Ning Jiang, Qijun Chen

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Abstract

Neutrophils are essential in combating invading pathogens such as Plasmodium parasites, but the participation of their subpopulations and mechanisms in resistance to parasite infection are not fully understood. Our study identified a marked increase in Ly6G⁺ neutrophils in response to P. berghei ANKA infection. Depletion of these cells rendered mice more susceptible to infection. Elevated interleukin-17 (IL-17) levels, which increased the Ly6G⁺ neutrophil population, were also found to contribute to this protective effect. IL-17 depletion led to reduced neutrophil numbers and increased susceptibility. Furthermore, dihydroartemisinin (DHA) treatment enhanced neutrophil-mediated immune responses through up-regulation of CD18 and CXCR4 factors. These findings revealed key mechanisms of neutrophil and IL-17 interactions in malaria protection and highlighted DHA's potential to promote neutrophil function in combating malaria.

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来源期刊

Research Multidisciplinary-Multidisciplinary

CiteScore

13.40

自引率

3.60%

发文量

审稿时长

14 weeks

期刊介绍： Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.