Ly6G⁺ Neutrophils and Interleukin-17 Are Essential in Protection against Rodent Malaria Caused by Plasmodium berghei ANKA.

IF 11 1区综合性期刊 Q1 Multidisciplinary

Research Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI:10.34133/research.0559

Ziwei Su, Qilong Li, Yiwei Zhang, Tong Liu, Kunying Lv, Anni Feng, Yixin Yang, Yanxin Zhang, Zhiming Wei, Xiaoyu Sang, Ying Feng, Ran Chen, Ning Jiang, Qijun Chen

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Abstract

Neutrophils are essential in combating invading pathogens such as Plasmodium parasites, but the participation of their subpopulations and mechanisms in resistance to parasite infection are not fully understood. Our study identified a marked increase in Ly6G⁺ neutrophils in response to P. berghei ANKA infection. Depletion of these cells rendered mice more susceptible to infection. Elevated interleukin-17 (IL-17) levels, which increased the Ly6G⁺ neutrophil population, were also found to contribute to this protective effect. IL-17 depletion led to reduced neutrophil numbers and increased susceptibility. Furthermore, dihydroartemisinin (DHA) treatment enhanced neutrophil-mediated immune responses through up-regulation of CD18 and CXCR4 factors. These findings revealed key mechanisms of neutrophil and IL-17 interactions in malaria protection and highlighted DHA's potential to promote neutrophil function in combating malaria.

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Ly6G+中性粒细胞和白细胞介素-17在预防伯氏疟原虫引起的啮齿动物疟疾中的作用

中性粒细胞在对抗入侵的病原体（如疟原虫）中是必不可少的，但它们的亚群和机制在抵抗寄生虫感染中的作用尚不完全清楚。我们的研究确定了Ly6G+中性粒细胞在伯氏假体ANKA感染反应中的显著增加。这些细胞的消耗使小鼠更容易受到感染。升高的白细胞介素-17 （IL-17）水平，增加了Ly6G+中性粒细胞的数量，也被发现有助于这种保护作用。IL-17缺失导致中性粒细胞数量减少和易感性增加。此外，双氢青蒿素（DHA）通过上调CD18和CXCR4因子，增强了中性粒细胞介导的免疫应答。这些发现揭示了中性粒细胞和IL-17相互作用在疟疾保护中的关键机制，并强调了DHA在促进中性粒细胞抗疟疾功能方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research Multidisciplinary-Multidisciplinary

CiteScore

13.40

自引率

3.60%

发文量

审稿时长

14 weeks

期刊介绍： Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.