Wuling capsule combined with sertraline in the therapy of anxiety and depression with insomnia in adolescents.

IF 3.9 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2024-12-19 DOI:10.5498/wjp.v14.i12.1860

Li-Li Duo, Gao-Feng Rao

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引用次数: 0

Abstract

Background: The treatment of adolescent patients with anxiety, depression and insomnia is challenging, and there is no ideal treatment method.

Aim: To evaluate the clinical efficacy of Wuling capsule combined with sertraline in the treatment of adolescent anxiety, depression and insomnia.

Methods: Eighty adolescent patients with anxiety, depression with insomnia who were admitted to our hospital from April 1, 2022 to March 30, 2024. And the subjects were randomly classified into the control group (n = 40) and the observational group (n = 40). The control group was treated with a combination of sertraline and placebo. The observation group was treated with Wuling capsule in addition to sertraline. The two groups were cured continuously for 8 weeks. Insomnia severity index (ISI), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were used to evaluate the clinical symptoms before treatment and at 2, 4, 6 and 8 weeks after treatment. The Treatment Emergent Symptom Scale (TESS) was used to evaluate adverse reactions during treatment.

Results: There was no obvious difference in HAMD, HAMA and ISI scores between the two groups before treatment (P > 0.05). After treatment, the HAMD, HAMA and ISI scores of patients in both groups decreased compared with before treatment, and HAMD, HAMA and ISI scores of patients in the observation group were remarkedly lower than those in the control group at each time point after treatment (P < 0.05). Compared with the control group, the TESS score of the study group were sharply lower (t = 18.239, P < 0.001).

Conclusion: Wuling capsule can further alleviate the insomnia symptoms of adolescents with anxiety and depression, and the efficacy and safety are high. It is recommended to promote the application.

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五灵胶囊联合舍曲林治疗青少年焦虑抑郁伴失眠。

背景：青少年焦虑、抑郁、失眠患者的治疗具有挑战性，目前尚无理想的治疗方法。目的：评价五灵胶囊联合舍曲林治疗青少年焦虑、抑郁、失眠的临床疗效。方法：选取2022年4月1日至2024年3月30日我院收治的80例青少年焦虑、抑郁伴失眠患者。将受试者随机分为对照组（n = 40）和观察组（n = 40）。对照组采用舍曲林和安慰剂联合治疗。观察组患者在舍曲林治疗的基础上给予五灵胶囊治疗。两组患者均连续治愈8周。采用失眠严重程度指数（ISI）、汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）评价治疗前及治疗后2、4、6、8周的临床症状。采用治疗紧急症状量表（TESS）评价治疗过程中的不良反应。结果：两组患者治疗前HAMD、HAMA、ISI评分比较，差异均无统计学意义（P < 0.05）。治疗后，两组患者HAMD、HAMA、ISI评分均较治疗前下降，且观察组患者HAMD、HAMA、ISI评分在治疗后各时间点均显著低于对照组（P < 0.05）。与对照组比较，研究组TESS评分显著降低（t = 18.239, P < 0.001）。结论：五灵胶囊能进一步缓解青少年焦虑抑郁的失眠症状，且疗效和安全性较高。建议推广应用。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.