Investigating the effect of echinacea extraction syrup on the outcomes of lower respiratory infections in patients with COVID-19: a randomized clinical trial study.

IF 4 3区 医学 Q2 VIROLOGY
Elham Kheirandish, Mehrsadat Mahdizadeh, Mousa Mahdizadeh, Fariba Rezaeitalab, Mahdi Yousefi, Seyedeh Sara Rezazadeh Shojaee
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引用次数: 0

Abstract

Introduction: Many COVID-19 patients experience mild to severe symptoms, including respiratory system involvement. Different treatment instructions have been suggested for patients with COVID-19. Echinacea has known antiviral effects. However, there is still not enough evidence that it is effective in treating COVID-19. This study was conducted with the aim of determining the effect of Echinacea extract syrup on the outcomes of the lower respiratory tract in patients with COVID-19.

Methods: In this single-blind randomized controlled trial, 40 patients with COVID-19 who were inpatients in the hospitals of Mashhad University of Medical Sciences, Iran, were randomly selected and assigned to two equal control and experimental groups (n = 20). In addition to receiving routine care and treatment (oxygen supply, remdesivir, enoxaparin and heparin), the experimental group received 5 cubic centimeter (CC) of Imogen syrup three times a day for 5 days each. The control group only received routine care and treatment. The data were collected on the first, third and fifth days after hospitalization and were analyzed using descriptive and analytical tests in Statistical Package for the Social Sciences (SPSS). The significance level was set at p < 0.05.

Results: The mean white blood cell count in the experimental group after the intervention decreased significantly compared to that before the intervention (t = 0.434, p = 0.045, df = 19). Arterial oxygen pressure increased significantly in both the experimental group (t = 4.382, p = 0.000, df = 19) and control group (t = 3.239, p = 0.004, df = 19), however no statistical differences were observed between experimental and control groups after intervention. The level of lung involvement (p = 0.320) and cough symptoms (P = 0.347) were not significantly different between the experimental and control groups after the intervention. In addition, there were no significant differences between the experimental and control groups in terms of the mean oxygen saturation, temperature, and number of breaths per minute on the first, third, and fifth day (p > 0.05).

Discussion: The consumption of Echinacea extract syrup may not be able to improve the symptoms of acute lower respiratory tract infection in patients with COVID-19 with 3 daily doses for 5 days. More studies should be conducted to investigate the clinical effects of Echinacea extract in the treatment of patients with pulmonary complications.

Trial registration: IRCT20130522013423N2.

紫锥菊提取物糖浆对COVID-19患者下呼吸道感染结局的影响:一项随机临床试验研究
导言:许多COVID-19患者出现轻度至重度症状,包括呼吸系统受累。针对COVID-19患者提出了不同的治疗方案。紫锥菊具有抗病毒作用。然而,仍然没有足够的证据表明它对治疗COVID-19有效。本研究旨在确定紫锥菊提取物糖浆对COVID-19患者下呼吸道结局的影响。方法:采用单盲随机对照试验,随机选择40例在伊朗马什哈德医科大学医院住院的新冠肺炎患者,随机分为对照组和实验组各20例。实验组患者在给予常规护理和治疗(供氧、瑞德西韦、依诺肝素、肝素)的基础上,给予伊莫金糖浆5立方厘米(CC),每日3次,连用5天。对照组患者仅接受常规护理和治疗。在住院后第1天、第3天和第5天收集数据,并使用社会科学统计软件包(SPSS)中的描述性和分析性检验进行分析。结果:实验组干预后平均白细胞计数较干预前显著下降(t = 0.434, p = 0.045, df = 19)。实验组和对照组的动脉氧压均显著升高(t = 4.382, p = 0.000, df = 19),但干预后实验组和对照组的动脉氧压差异无统计学意义(t = 3.239, p = 0.004, df = 19)。干预后实验组与对照组肺受累程度(p = 0.320)、咳嗽症状(p = 0.347)差异无统计学意义。此外,实验组与对照组在第1天、第3天、第5天的平均血氧饱和度、体温、每分钟呼吸次数均无显著差异(p < 0.05)。讨论:每日3次连续5天服用紫锥菊提取物糖浆可能不能改善COVID-19患者急性下呼吸道感染的症状。紫锥菊提取物治疗肺部并发症的临床疗效有待进一步研究。试验注册:IRCT20130522013423N2。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Virology Journal
Virology Journal 医学-病毒学
CiteScore
7.40
自引率
2.10%
发文量
186
审稿时长
1 months
期刊介绍: Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.
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