40 Hz visual stimulation during sleep evokes neuronal gamma activity in NREM and REM stages.

IF 5.6 2区 医学 Q1 Medicine
Sleep Pub Date : 2025-03-11 DOI:10.1093/sleep/zsae299
Laura Hainke, James Dowsett, Manuel Spitschan, Josef Priller
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引用次数: 0

Abstract

Study objectives: Visual stimulation (VS) at 40 Hz is being tested as a non-invasive approach against dementias such as Alzheimer's disease. Applying it during sleep could increase the convenience, duration, and efficacy of stimulation. Here, we tested the feasibility of 40 Hz VS during sleep in a proof-of-concept study.

Methods: Thirty healthy participants underwent one control and one experimental night of polysomnography at the sleep laboratory. 40 Hz VS was delivered in wakefulness (W), NREM sleep stages 2 and 3, and REM sleep.

Results: As expected, 40 Hz EEG spectral power was increased in all four stages in the experimental condition, compared to control. It was highest in W and similar across NREM 2, NREM 3, and REM, with large and medium effect sizes, respectively. Steady-state visually evoked potential (SSVEP) analyses in the time domain confirmed the specificity of the effect. Secondary analyses revealed that the intervention did not impair objective and subjective sleep quality beyond the first-night effect.

Conclusions: 40 Hz VS during sleep effectively evoked neuronal gamma activity at stimulation frequency without degrading sleep quality, supporting the feasibility of this approach. These findings lay the groundwork for optimizing gamma-band sensory stimulation as a tool to causally study cognitive functions and as a scalable, non-invasive intervention against dementias.

40赫兹的视觉刺激在睡眠中唤醒非快速眼动和快速眼动阶段的神经元伽马活动。
研究目标:40赫兹的视觉刺激正在作为一种非侵入性的治疗老年痴呆症的方法进行测试,如阿尔茨海默病。在睡眠中使用它可以增加刺激的便利性,持续时间和效果。在这里,我们在一项概念验证研究中测试了睡眠期间40赫兹视觉刺激的可行性。方法:30名健康受试者在睡眠实验室分别进行1个对照组和1个实验夜的多导睡眠描记术。在清醒(W)、非快速眼动睡眠阶段2和3以及快速眼动睡眠阶段给予40 Hz的视觉刺激。结果:与对照组相比,实验条件下4个阶段的40 Hz脑电频谱功率均有所增加。在第2期、第3期和第3期中,W期的效应值最高,效应值相近,分别为大、中效应值。时域稳态视觉诱发电位(SSVEP)分析证实了该效应的特异性。二次分析显示,除了第一晚的影响外,干预并没有损害客观和主观的睡眠质量。结论:睡眠时40 Hz的视觉刺激能有效激发神经元γ活动,且不降低睡眠质量,支持该方法的可行性。这些发现为优化伽玛波段感觉刺激作为因果研究认知功能的工具以及作为一种可扩展的、非侵入性的痴呆症干预手段奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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