40 Hz Visual Stimulation During Sleep Evokes Neuronal Gamma Activity in NREM and REM Stages.

IF 5.6 2区 医学 Q1 Medicine
Sleep Pub Date : 2024-12-19 DOI:10.1093/sleep/zsae299
Laura Hainke, James Dowsett, Manuel Spitschan, Josef Priller
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引用次数: 0

Abstract

Study objectives: Visual stimulation at 40 Hz is being tested as a non-invasive approach against dementias such as Alzheimer's disease. Applying it during sleep could increase convenience, duration, and efficacy of stimulation. Here, we tested the feasibility of 40 Hz visual stimulation during sleep in a proof-of-concept study.

Methods: 30 healthy participants underwent one control and one experimental night of polysomnography at the sleep laboratory. 40 Hz visual stimulation was delivered in wakefulness (W), NREM sleep stages 2 and 3, and REM sleep.

Results: As expected, 40 Hz EEG spectral power was increased in all four stages in the experimental condition, compared to control. It was highest in W and similar across NREM 2, NREM 3, and REM, with large and medium effect sizes, respectively. Steady-State Visually Evoked Potential (SSVEP) analyses in the time domain confirmed the specificity of the effect. Secondary analyses revealed that the intervention did not impair objective and subjective sleep quality beyond the first night effect.

Conclusion: 40 Hz visual stimulation during sleep effectively evoked neuronal gamma activity at stimulation frequency without degrading sleep quality, supporting the feasibility of this approach. These findings lay the groundwork for optimizing gamma-band sensory stimulation as a tool to causally study cognitive functions and as a scalable, non-invasive intervention against dementias.

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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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