Hendersines J–M: Isoquinoline alkaloids from Corydalis hendersonii Hemsl. with cardiomyocyte protective and NO production inhibitory effects

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-12-17 DOI:10.1016/j.phytochem.2024.114365

Xiaochun Zhou , Zefeng Zhang , Changxin Liu , Shungang Jiao , Fuxing Ge , Qiuyuan Ding , Yiru Shen , Qiang Guo , Xingyun Chai

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Abstract

Six isoquinoline alkaloids were identified from the alkaloid-rich fraction of Corydalis hendersonii Hemsl, including five previously undescribed isoquinoline alkaloids hendersines J–M (1a, 1b, and 2–4) and isobicuculline (5), a compound reported for the first time from a natural source. Their structures were elucidated based on spectroscopic analysis of HR-ESI-MS, 1D and 2D NMR, X-ray diffraction, and ECD. Compounds 1a and 1b represent a pair of rare three-nitrogen isoquinoline alkaloid enantiomers, while 2 and 3 are isoquinoline alkaloids featuring a benzo-fused N-heterocycle. Compounds 1a and 3 exhibited moderate protective effects against oxygen-glucose deprivation-induced H9c2 cells injury, 1b and 2 showed moderate inhibitory effects on NO production in lipopolysaccharide-induced RAW264.7 cells.

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黄连素J-M：黄连中的异喹啉类生物碱。具有心肌细胞保护和NO生成抑制作用。

从含丰富生物碱的延胡索（yydalis hendersonii Hemsl）中鉴定出6种异喹啉类生物碱，包括5种此前未被报道的异喹啉类生物碱hendersines J-M （1a、1b和2-4）和首次从天然来源中报道的异喹啉类生物碱isobiculline(5)。通过HR-ESI-MS、1D和2D NMR、x射线衍射和ECD对其结构进行了表征。化合物1a和1b是一对罕见的三氮异喹啉生物碱对映体，而2和3是具有苯并融合n杂环的异喹啉生物碱。化合物1a和3对氧葡萄糖剥夺诱导的H9c2细胞损伤有中等保护作用，化合物1b和2对脂多糖诱导的RAW264.7细胞NO生成有中等抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.