The emerging role of long non-coding RNA SOX2-OT in cancers and non-malignant diseases.

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of physiology and biochemistry Pub Date : 2024-12-20 DOI:10.1007/s13105-024-01059-2

Jingjie Yang, Fangshun Tan, Yaohui Chen, Xiaolan Li, Chengfu Yuan

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引用次数: 0

Abstract

SOX2 overlapping transcript (SOX2-OT) is a long non-coding RNA located at chromosome 3q26.33 in humans. Convincing data confirm that SOX2-OT is evolutionarily conserved and plays a significant role in various malignant and non-malignant diseases. In most cancers, the upregulation of SOX2-OT acts as an oncogenic factor, strongly correlating with tumor risk, adverse clinicopathological features, and poor prognosis. Mechanistically, SOX2-OT is regulated by seven transcription factors and influences cellular behavior by modulating SOX2 expression, competitively binding 20 types of miRNAs, stabilizing protein expression, or promoting protein ubiquitination. It also participates in epigenetic modifications and activates multiple signaling pathways to regulate cancer cell proliferation, apoptosis, migration, invasion, autophagy, immune evasion, and resistance to chemotherapy/targeted therapies. Additionally, SOX2-OT triggers apoptosis, oxidative stress, and inflammatory responses, contributing to neurodevelopmental disorders, cardiovascular diseases, and diabetes-related conditions. Genetic polymorphisms of SOX2-OT have also been linked to breast cancer, gastric cancer, recurrent miscarriage, sepsis, and eating disorders in patients with bipolar disorder. This review provides an overview of recent research progress on SOX2-OT in human diseases, highlights its substantial potential as a prognostic and diagnostic biomarker, and explores its future clinical applications.

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长链非编码RNA SOX2-OT在癌症和非恶性疾病中的新作用

SOX2 重叠转录本（SOX2-OT）是一种非编码长 RNA，位于人类染色体 3q26.33 上。令人信服的数据证实，SOX2-OT 在进化上是保守的，并在各种恶性和非恶性疾病中发挥着重要作用。在大多数癌症中，SOX2-OT 的上调是一种致癌因子，与肿瘤风险、不良临床病理特征和不良预后密切相关。从机制上讲，SOX2-OT 受七种转录因子调控，通过调节 SOX2 表达、竞争性结合 20 种 miRNA、稳定蛋白质表达或促进蛋白质泛素化等方式影响细胞行为。它还参与表观遗传修饰，激活多种信号通路，以调控癌细胞增殖、凋亡、迁移、侵袭、自噬、免疫逃避和对化疗/靶向疗法的抗性。此外，SOX2-OT 还会引发细胞凋亡、氧化应激和炎症反应，导致神经发育障碍、心血管疾病和糖尿病相关疾病。SOX2-OT的基因多态性还与乳腺癌、胃癌、复发性流产、败血症以及躁郁症患者的饮食失调有关。本综述概述了有关 SOX2-OT 在人类疾病中的最新研究进展，强调了其作为预后和诊断生物标志物的巨大潜力，并探讨了其未来的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of physiology and biochemistry 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiology and Biochemistry publishes original research articles and reviews describing relevant new observations on molecular, biochemical and cellular mechanisms involved in human physiology. All areas of the physiology are covered. Special emphasis is placed on the integration of those levels in the whole-organism. The Journal of Physiology and Biochemistry also welcomes articles on molecular nutrition and metabolism studies, and works related to the genomic or proteomic bases of the physiological functions. Descriptive manuscripts about physiological/biochemical processes or clinical manuscripts will not be considered. The journal will not accept manuscripts testing effects of animal or plant extracts.